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    Uxs1 UDP-glucuronate decarboxylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67883, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Uxs1provided by MGI
    Official Full Name
    UDP-glucuronate decarboxylase 1provided by MGI
    Primary source
    MGI:MGI:1915133
    See related
    Ensembl:ENSMUSG00000057363 AllianceGenome:MGI:1915133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1600025I13Rik
    Summary
    Predicted to enable NAD+ binding activity; UDP-glucuronate decarboxylase activity; and protein homodimerization activity. Located in mitochondrion. Is expressed in forelimb and hindlimb. Orthologous to human UXS1 (UDP-glucuronate decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.7), placenta adult (RPKM 8.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C1.1; 1 23.46 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (43786121..43866999, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (43746961..43827839, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30634 Neighboring gene ECRG4 augurin precursor Neighboring gene STARR-positive B cell enhancer mm9_chr1:43834650-43834950 Neighboring gene STARR-positive B cell enhancer mm9_chr1:43835251-43835552 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene ADP-ribosylation factor 1 pseudogene Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 27 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid. Eixelsberger T, et al. J Biol Chem, 2012 Sep 7. PMID 22810237, Free PMC Article
    2. Locus of the gene 'fidget' in the house mouse. WALLACE ME. Nature, 1950 Sep 2. PMID 14775691
    3. UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. Moriarity JL, et al. J Biol Chem, 2002 May 10. PMID 11877387
    4. Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. Rios JJ, et al. J Bone Miner Res, 2021 Aug. PMID 33905568, Free PMC Article
    5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucuronate decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-D-xylose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    UDP-glucuronic acid decarboxylase 1
    Names
    UGD
    UXS-1
    NP_001355216.1
    NP_001355217.1
    NP_001355218.1
    NP_080706.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368287.1 → NP_001355216.1  UDP-glucuronic acid decarboxylase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC159092

    2. NM_001368288.1 → NP_001355217.1  UDP-glucuronic acid decarboxylase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 4, encodes isoform 3.
      Source sequence(s)
      AC159092
      Conserved Domains (2) summary
      cd05230
      Location:50 → 353
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      pfam11803
      Location:1 → 39
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    3. NM_001368289.1 → NP_001355218.1  UDP-glucuronic acid decarboxylase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 3, encodes isoform 3.
      Source sequence(s)
      AC159092
      Conserved Domains (2) summary
      cd05230
      Location:50 → 353
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      pfam11803
      Location:1 → 39
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    4. NM_026430.4 → NP_080706.1  UDP-glucuronic acid decarboxylase 1 isoform 2

      See identical proteins and their annotated locations for NP_080706.1

      Status: VALIDATED

      Source sequence(s)
      AC159092
      Consensus CDS
      CCDS35551.1
      UniProtKB/Swiss-Prot
      Q3U854, Q91XL3
      Related
      ENSMUSP00000119939.2, ENSMUST00000126008.8
      Conserved Domains (2) summary
      cd05230
      Location:89 → 392
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      pfam11803
      Location:4 → 78
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    RNA

    1. NR_160749.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159092, AK005536

    2. NR_160750.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159092

    3. NR_160751.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159092

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      43786121..43866999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XL3.1 GenPept UniProtKB/Swiss-Prot:Q91XL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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