Asprv1 aspartic peptidase, retroviral-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asprv1provided by MGI
Official Full Name: aspartic peptidase, retroviral-like 1provided by MGI
Primary source: MGI:MGI:1915105
See related: Ensembl:ENSMUSG00000033508 AllianceGenome:MGI:1915105
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SASP; Taps; SASPase; 2300003P22Rik
Summary: Enables aspartic-type endopeptidase activity. Involved in protein processing and skin development. Predicted to be located in membrane. Is expressed in anterior naris and external naris. Orthologous to human ASPRV1 (aspartic peptidase retroviral like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 37.75 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (86605216..86606692)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (86628174..86629710)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

aberrant Taps expression causes impaired skin regeneration and skin remodeling after cutaneous injury and chemically induced hyperplasia
Title: Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice.
Detection of Taps levels represents a novel strategy to discriminate the progression state of squamous skin cancers.
Title: A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin.
the retroviral-like aspartic protease, SASPase, is involved in prevention of fine wrinkle formation via activation in a weakly acidic stratum corneum environment
Title: Mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA986851 (e-PCR)
- UniSTS:165474

NoName (e-PCR)
- UniSTS:491475

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in skin development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: retroviral-like aspartic protease 1

Names: TPA-inducible aspartic proteinase-like protein; skin aspartic protease; skin-specific retroviral-like aspartic protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026414.3 → NP_080690.3 retroviral-like aspartic protease 1

Status: VALIDATED

Source sequence(s)

DQ841260

Consensus CDS

CCDS39542.1

UniProtKB/TrEMBL

A0A8D3UE05

Related

ENSMUSP00000046121.8, ENSMUST00000043400.9

Conserved Domains (1) summary

cd00303
Location:113 → 205

retropepsin_like; Retropepsins; pepsin-like aspartate proteases