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    Ddx55 DEAD box helicase 55 [ Mus musculus (house mouse) ]

    Gene ID: 67848, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ddx55provided by MGI
    Official Full Name
    DEAD box helicase 55provided by MGI
    Primary source
    MGI:MGI:1915098
    See related
    Ensembl:ENSMUSG00000029389 AllianceGenome:MGI:1915098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1595; 2810021H22Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleolus. Is expressed in embryo. Orthologous to human DDX55 (DEAD-box helicase 55). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.5), CNS E18 (RPKM 5.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 63.66 cM; 5 F
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124690895..124707723)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124552832..124569660)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Rab interacting lysosomal protein-like 1 Neighboring gene ribosomal protein L32 5C pseudogene Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3619 Neighboring gene STARR-positive B cell enhancer ABC_E3620 Neighboring gene eukaryotic translation initiation factor 2B, subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E8083 Neighboring gene general transcription factor IIH, polypeptide 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC143677, MGC143678

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX55
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
    DEAD box protein 55
    NP_001177724.1
    NP_080685.2
    XP_036021336.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190795.1 → NP_001177724.1  ATP-dependent RNA helicase DDX55 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      BC043052, BY202366
      Consensus CDS
      CCDS57380.1
      UniProtKB/TrEMBL
      E9Q9T6, Q810A4
      Related
      ENSMUSP00000107065.2, ENSMUST00000111438.2
      Conserved Domains (4) summary
      COG0513
      Location:2 → 513
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00268
      Location:9 → 224
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:252 → 363
      Helicase_C; Helicase conserved C-terminal domain
      pfam13959
      Location:399 → 458
      DUF4217; Domain of unknown function (DUF4217)

    2. NM_026409.4 → NP_080685.2  ATP-dependent RNA helicase DDX55 isoform 1

      See identical proteins and their annotated locations for NP_080685.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK033741, BC043052, BY202366
      Consensus CDS
      CCDS39281.1
      UniProtKB/Swiss-Prot
      Q149H5, Q3U460, Q6ZPL9, Q8BZR1
      UniProtKB/TrEMBL
      Q810A4
      Related
      ENSMUSP00000070279.8, ENSMUST00000071057.14
      Conserved Domains (4) summary
      smart00487
      Location:24 → 228
      DEXDc; DEAD-like helicases superfamily
      cd00268
      Location:9 → 224
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:252 → 363
      Helicase_C; Helicase conserved C-terminal domain
      pfam13959
      Location:403 → 462
      DUF4217; Domain of unknown function (DUF4217)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124690895..124707723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165443.1 → XP_036021336.1  ATP-dependent RNA helicase DDX55 isoform X1

      Conserved Domains (2) summary
      COG0513
      Location:16 → 231
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam13959
      Location:258 → 315
      DUF4217; Domain of unknown function (DUF4217)

    RNA

    1. XR_387576.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZPL9.2 GenPept UniProtKB/Swiss-Prot:Q6ZPL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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