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    Mrpl57 mitochondrial ribosomal protein L57 [ Mus musculus (house mouse) ]

    Gene ID: 67840, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mrpl57provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L57provided by MGI
    Primary source
    MGI:MGI:1915090
    See related
    Ensembl:ENSMUSG00000021967 AllianceGenome:MGI:1915090
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrp63; 2610025P17Rik
    Summary
    A structural constituent of ribosome. Acts upstream of or within translation. Located in mitochondrial ribosome. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL57 (mitochondrial ribosomal protein L57). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 14.2), adrenal adult (RPKM 13.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 C3; 14 30.51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (58063662..58066544)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57826228..57829087)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene large tumor suppressor 2 Neighboring gene predicted gene, 52140 Neighboring gene STARR-seq mESC enhancer starr_36815 Neighboring gene microRNA 3077 Neighboring gene Sin3-associated polypeptide 18 Neighboring gene STARR-positive B cell enhancer ABC_E10829 Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene predicted gene, 22738 Neighboring gene zinc finger, DHHC domain containing 20 Neighboring gene STARR-seq mESC enhancer starr_36817 Neighboring gene STARR-seq mESC enhancer starr_36818 Neighboring gene STARR-positive B cell enhancer ABC_E7320

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041
    2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrial ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL63
    Names
    mMRP63
    mitochondrial ribosomal protein 63
    mitochondrial ribosomal protein L53
    ribosomal protein 63, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026401.2 → NP_080677.1  large ribosomal subunit protein mL63

      See identical proteins and their annotated locations for NP_080677.1

      Status: PROVISIONAL

      Source sequence(s)
      AK011558
      Consensus CDS
      CCDS27161.1
      UniProtKB/Swiss-Prot
      Q9CQF8
      Related
      ENSMUSP00000022538.4, ENSMUST00000022538.5
      Conserved Domains (1) summary
      pfam14978
      Location:14 → 101
      MRP-63; Mitochondrial ribosome protein 63

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      58063662..58066544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519478.2 → XP_006519541.1  large ribosomal subunit protein mL63 isoform X1

      See identical proteins and their annotated locations for XP_006519541.1

      UniProtKB/Swiss-Prot
      Q9CQF8
      Conserved Domains (1) summary
      pfam14978
      Location:14 → 101
      MRP-63; Mitochondrial ribosome protein 63
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQF8.1 GenPept UniProtKB/Swiss-Prot:Q9CQF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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