Aadac arylacetamide deacetylase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aadacprovided by MGI
Official Full Name: arylacetamide deacetylaseprovided by MGI
Primary source: MGI:MGI:1915008
See related: Ensembl:ENSMUSG00000027761 AllianceGenome:MGI:1915008
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aada; 5033417E09Rik
Summary: Enables serine hydrolase activity and triglyceride lipase activity. Involved in positive regulation of triglyceride catabolic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human AADAC (arylacetamide deacetylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 132.8), liver adult (RPKM 84.1) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 D; 3 29.17 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (59939209..59947578)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (60031788..60040157)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vitro deacetylation of N-acetylserotonin by arylacetamide deacetylase.
Title: In vitro deacetylation of N-acetylserotonin by arylacetamide deacetylase.
AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation.
Title: AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation.
Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency.
Title: Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency.
Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans.
Title: Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans.
Expression of AADA cDNA in McArdle-RH7777 cells significantly reduced intracellular triacylglycerol levels and apolipoprotein B secretion and increased fatty acid oxidation.
Title: Arylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables deacetylase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	TAS Traceable Author Statement more info	PubMed
enables serine hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine hydrolase activity	ISO Inferred from Sequence Orthology more info
enables triglyceride lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triglyceride lipase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of triglyceride catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arylacetamide deacetylase

Names: arylacetamide deacetylase (esterase)

NP_075872.1

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023383.1 → NP_075872.1 arylacetamide deacetylase

See identical proteins and their annotated locations for NP_075872.1

Status: VALIDATED

Source sequence(s)

AF306788

Consensus CDS

CCDS17375.1

UniProtKB/Swiss-Prot

Q8VCF2, Q99PG0

Related

ENSMUSP00000029325.4, ENSMUST00000029325.5

Conserved Domains (2) summary

COG0657
Location:26 → 373

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam07859
Location:106 → 356

Abhydrolase_3; alpha/beta hydrolase fold