Spc24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spc24provided by MGI
Official Full Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:1914879
See related: Ensembl:ENSMUSG00000074476 AllianceGenome:MGI:1914879
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spbc24; 2410030K01Rik
Summary: Predicted to contribute to microtubule binding activity. Predicted to be involved in chromosome segregation. Predicted to act upstream of or within cell division. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Ndc80 complex. Is expressed in cerebral cortex; cerebral cortex ventricular layer; diencephalon lateral wall ventricular layer; midbrain ventricular layer; and telencephalon ventricular layer. Orthologous to human SPC24 (SPC24 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 17.7), liver E14.5 (RPKM 17.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.88 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21666730..21671741, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21755434..21760446, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spc24 plays an important role in genomic stability maintenance during oocyte meiotic maturation.
Title: Spc24 is required for meiotic kinetochore-microtubule attachment and production of euploid eggs.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493084

AV109292 (e-PCR)
- UniSTS:179864

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of Ndc80 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ndc80 complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	NAS Non-traceable Author Statement more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinetochore protein Spc24

Names: spindle pole body component 24 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357331.1 → NP_001344260.1 kinetochore protein Spc24 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate coding exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC161371, BC056965

Consensus CDS

CCDS90517.1

UniProtKB/TrEMBL

A0A1L1SV84

Related

ENSMUSP00000151082.2, ENSMUST00000216057.2

Conserved Domains (2) summary

pfam08286
Location:83 → 129

Spc24; Spc24 subunit of Ndc80

cl25732
Location:35 → 129

SMC_N; RecF/RecN/SMC N terminal domain
NM_026282.6 → NP_080558.1 kinetochore protein Spc24 isoform 1

See identical proteins and their annotated locations for NP_080558.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC161371, AK011728

Consensus CDS

CCDS40554.1

UniProtKB/Swiss-Prot

Q3TIF5, Q8CD13, Q9D083

UniProtKB/TrEMBL

Q14BA9

Related

ENSMUSP00000096541.5, ENSMUST00000098942.6

Conserved Domains (2) summary

pfam01496
Location:40 → 124

V_ATPase_I; V-type ATPase 116kDa subunit family

pfam08286
Location:83 → 192

Spc24; Spc24 subunit of Ndc80

RNA

NR_151672.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC161371
NR_151673.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC161371