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    Narf nuclear prelamin A recognition factor [ Mus musculus (house mouse) ]

    Gene ID: 67608, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Narfprovided by MGI
    Official Full Name
    nuclear prelamin A recognition factorprovided by MGI
    Primary source
    MGI:MGI:1914858
    See related
    Ensembl:ENSMUSG00000000056 AllianceGenome:MGI:1914858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4430402O11Rik
    Summary
    Predicted to enable lamin binding activity. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in lamin filament. Is expressed in liver lobe; nervous system; and neural retina. Orthologous to human NARF (nuclear prelamin A recognition factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 24.8), liver E14.5 (RPKM 24.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E2; 11 85.12 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121128062..121146682)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121237236..121255856)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E7117 Neighboring gene hexosaminidase D Neighboring gene STARR-positive B cell enhancer ABC_E5315 Neighboring gene STARR-seq mESC enhancer starr_31378 Neighboring gene STARR-positive B cell enhancer ABC_E8883 Neighboring gene cytochrome b 245 chaperone 1 Neighboring gene forkhead box K2 Neighboring gene WD repeat domain 45B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification. Yang Y, et al. Sci Adv, 2022 Dec 9. PMID 36490339, Free PMC Article
    2. Extracellular matrix remodeling and transforming growth factor-β signaling abnormalities induced by lamin A/C variants that cause lipodystrophy. Le Dour C, et al. J Lipid Res, 2017 Jan. PMID 27845687, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification.
      Title: NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lamin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear prelamin A recognition factor
    Names
    IOP2
    iron-only hydrogenase-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026272.3 → NP_080548.3  nuclear prelamin A recognition factor

      See identical proteins and their annotated locations for NP_080548.3

      Status: VALIDATED

      Source sequence(s)
      AK081305, BC016090, BM951066
      Consensus CDS
      CCDS25772.1
      UniProtKB/Swiss-Prot
      Q8BVW9, Q9CYQ7
      Related
      ENSMUSP00000099304.4, ENSMUST00000103015.4
      Conserved Domains (3) summary
      smart00902
      Location:404 → 452
      Fe_hyd_SSU; Iron hydrogenase small subunit
      COG4624
      Location:49 → 449
      Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
      pfam02906
      Location:98 → 390
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      121128062..121146682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYQ7.1 GenPept UniProtKB/Swiss-Prot:Q9CYQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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