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    Kcnv1 potassium channel, subfamily V, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 67498, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kcnv1provided by MGI
    Official Full Name
    potassium channel, subfamily V, member 1provided by MGI
    Primary source
    MGI:MGI:1914748
    See related
    Ensembl:ENSMUSG00000022342 AllianceGenome:MGI:1914748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    vibe; 2700023A03Rik
    Summary
    Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Orthologous to human KCNV1 (potassium voltage-gated channel modifier subfamily V member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 3.4), frontal lobe adult (RPKM 2.6) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnv1 in Genome Data Viewer
    Location:
    15 B3.3; 15 17.25 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (44959482..44979375, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (45096086..45115912, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38579 Neighboring gene H3 histone, family 3B pseudogene Neighboring gene predicted pseudogene 5471 Neighboring gene STARR-seq mESC enhancer starr_38580 Neighboring gene STARR-seq mESC enhancer starr_38581 Neighboring gene STARR-seq mESC enhancer starr_38582 Neighboring gene predicted gene, 57628 Neighboring gene STARR-seq mESC enhancer starr_38583 Neighboring gene STARR-seq mESC enhancer starr_38585 Neighboring gene STARR-seq mESC enhancer starr_38586 Neighboring gene STARR-seq mESC enhancer starr_38587 Neighboring gene STARR-seq mESC enhancer starr_38588 Neighboring gene STARR-seq mESC enhancer starr_38589 Neighboring gene STARR-seq mESC enhancer starr_38590 Neighboring gene Kruppel-like factor 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily V member 1
    Names
    neuronal potassium channel alpha subunit
    potassium channel Kv8.1 homolog
    voltage-gated potassium channel subunit Kv8.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026200.3 → NP_080476.2  potassium voltage-gated channel subfamily V member 1

      See identical proteins and their annotated locations for NP_080476.2

      Status: VALIDATED

      Source sequence(s)
      AK034091, AK139482, CJ151712
      Consensus CDS
      CCDS27459.1
      UniProtKB/Swiss-Prot
      Q8BK61, Q8BYS7, Q8BZN2, Q9CZR1
      Related
      ENSMUSP00000022967.6, ENSMUST00000022967.7
      Conserved Domains (2) summary
      cl38908
      Location:44 → 163
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:212 → 438
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      44959482..44979375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521297.5 → XP_006521360.1  potassium voltage-gated channel subfamily V member 1 isoform X1

      See identical proteins and their annotated locations for XP_006521360.1

      UniProtKB/Swiss-Prot
      Q8BK61, Q8BYS7, Q8BZN2, Q9CZR1
      Conserved Domains (2) summary
      cl38908
      Location:44 → 163
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:212 → 438
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZN2.2 GenPept UniProtKB/Swiss-Prot:Q8BZN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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