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    Mettl16 methyltransferase 16, N6-methyladenosine [ Mus musculus (house mouse) ]

    Gene ID: 67493, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Mettl16provided by MGI
    Official Full Name
    methyltransferase 16, N6-methyladenosineprovided by MGI
    Primary source
    MGI:MGI:1914743
    See related
    Ensembl:ENSMUSG00000010554 AllianceGenome:MGI:1914743
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mett10d; 2610100D03Rik; 2810013M15Rik; A830095F14Rik
    Summary
    Enables mRNA (N6-adenosine)-methyltransferase activity. Involved in mRNA catabolic process; mRNA destabilization; and mRNA methylation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human METTL16 (methyltransferase 16, N6-methyladenosine). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.5), CNS E18 (RPKM 2.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 45.76 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74661658..74716649)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74770815..74826855)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29969 Neighboring gene predicted gene, 24211 Neighboring gene predicted gene, 40198 Neighboring gene STARR-seq mESC enhancer starr_29970 Neighboring gene STARR-seq mESC enhancer starr_29971 Neighboring gene STARR-positive B cell enhancer ABC_E3000 Neighboring gene predicted gene, 57584 Neighboring gene STARR-positive B cell enhancer ABC_E8879 Neighboring gene STARR-positive B cell enhancer ABC_E11484 Neighboring gene STARR-positive B cell enhancer ABC_E7015 Neighboring gene max binding protein Neighboring gene small G protein signaling modulator 2 Neighboring gene microRNA 6926

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Methylation of Structured RNA by the m(6)A Writer METTL16 Is Essential for Mouse Embryonic Development. Mendel M, et al. Mol Cell, 2018 Sep 20. PMID 30197299, Free PMC Article
    2. S-Adenosylmethionine Synthesis Is Regulated by Selective N(6)-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1. Shima H, et al. Cell Rep, 2017 Dec 19. PMID 29262316
    3. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Gehman LT, et al. Genes Dev, 2012 Mar 1. PMID 22357600, Free PMC Article
    4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U6 snRNA 3'-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA m(6)A methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA m(6)A methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of S-adenosylmethionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of S-adenosylmethionine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-transcriptional regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA (adenine-N6)-methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA N6-adenosine-methyltransferase METTL16
    Names
    N6-adenosine-methyltransferase METTL16
    U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
    methyltransferase 10 domain containing
    methyltransferase 10 domain-containing protein
    methyltransferase like 16
    methyltransferase-like protein 16
    putative methyltransferase METT10D
    NP_080473.1
    XP_006534061.1
    XP_006534062.1
    XP_006534063.1
    XP_006534064.1
    XP_017170208.1
    XP_030102109.1
    XP_036012804.1
    XP_036012805.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026197.3 → NP_080473.1  RNA N6-adenosine-methyltransferase METTL16

      See identical proteins and their annotated locations for NP_080473.1

      Status: PROVISIONAL

      Source sequence(s)
      AL604066, AL607024
      Consensus CDS
      CCDS25036.1
      UniProtKB/Swiss-Prot
      Q3UMA9, Q9CQG2, Q9D062
      UniProtKB/TrEMBL
      Q5SW15
      Related
      ENSMUSP00000114682.2, ENSMUST00000141755.8
      Conserved Domains (1) summary
      cl17173
      Location:1 → 291
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      74661658..74716649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156911.1 → XP_036012804.1  RNA N6-adenosine-methyltransferase METTL16 isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:1 → 73
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_006533998.5 → XP_006534061.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

      See identical proteins and their annotated locations for XP_006534061.1

      UniProtKB/Swiss-Prot
      Q3UMA9, Q9CQG2, Q9D062
      UniProtKB/TrEMBL
      Q5SW15
      Conserved Domains (1) summary
      cl17173
      Location:1 → 291
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_006533999.4 → XP_006534062.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

      See identical proteins and their annotated locations for XP_006534062.1

      UniProtKB/Swiss-Prot
      Q3UMA9, Q9CQG2, Q9D062
      UniProtKB/TrEMBL
      Q5SW15
      Conserved Domains (1) summary
      cl17173
      Location:1 → 291
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_017314719.3 → XP_017170208.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      UniProtKB/TrEMBL
      Q5SW15
      Conserved Domains (1) summary
      cl17173
      Location:1 → 244
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_036156912.1 → XP_036012805.1  RNA N6-adenosine-methyltransferase METTL16 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:23 → 71
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    6. XM_006534001.4 → XP_006534064.1  RNA N6-adenosine-methyltransferase METTL16 isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:1 → 73
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    7. XM_030246249.2 → XP_030102109.1  RNA N6-adenosine-methyltransferase METTL16 isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:1 → 73
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    8. XM_006534000.5 → XP_006534063.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      UniProtKB/TrEMBL
      Q5SW15
      Conserved Domains (1) summary
      cl17173
      Location:1 → 244
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_004937007.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQG2.1 GenPept UniProtKB/Swiss-Prot:Q9CQG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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