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    Slc47a1 solute carrier family 47, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 67473, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc47a1provided by MGI
    Official Full Name
    solute carrier family 47, member 1provided by MGI
    Primary source
    MGI:MGI:1914723
    See related
    Ensembl:ENSMUSG00000010122 AllianceGenome:MGI:1914723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MATE1; mMATE1; 1300013J15Rik
    Summary
    Predicted to enable L-arginine transmembrane transporter activity; amide transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Predicted to be involved in L-arginine import across plasma membrane; organic cation transport; and xenobiotic transport. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and vesicle. Predicted to be active in membrane. Is expressed in several structures, including liver; lung; metanephros; nervous system; and spleen. Orthologous to human SLC47A1 (solute carrier family 47 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 97.2), liver adult (RPKM 32.0) and 3 other tissues See more
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    Genomic context

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    Location:
    11 B2; 11 37.96 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61234226..61269668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61343400..61378842, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase family 3, subfamily A2 Neighboring gene STARR-positive B cell enhancer ABC_E6993 Neighboring gene STARR-seq mESC enhancer starr_29673 Neighboring gene STARR-seq mESC enhancer starr_29674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61123776-61123977 Neighboring gene solute carrier family 47, member 2 Neighboring gene predicted gene, 25929 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 12 Neighboring gene STARR-seq mESC enhancer starr_29676 Neighboring gene predicted gene, 42081 Neighboring gene STARR-positive B cell enhancer ABC_E6994 Neighboring gene nuclear encoded tRNA trytophan 5 (anticodon CCA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity. Waissbluth S, et al. Acta Otolaryngol, 2023 Mar. PMID 36943799
    2. MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia. Uddin ME, et al. Int J Mol Sci, 2022 Aug 3. PMID 35955741, Free PMC Article
    3. Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease. Liu H, et al. Nat Genet, 2022 Jul. PMID 35710981
    4. Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C]Metformin in Mouse. Shingaki T, et al. Pharm Res, 2015 Aug. PMID 25715695
    5. The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo. Hume WE, et al. Bioorg Med Chem, 2013 Dec 15. PMID 24238901

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity.
      Title: MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity.
    2. The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.
      Title: The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.
    3. Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
      Title: Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
    4. Tissue concentration based investigations using [(11)C]metformin by PET enables the functional analysis of MATEs in the liver and kidneys
      Title: Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C]Metformin in Mouse.
    5. Mate1 mRNA expression was decreased in mice with either the ob/ob model or the methionine/choline deficiency model of nonalcoholic steatohepatitis.
      Title: Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.
    6. MATE1 was highly expressed in peroxisomes and the endoplasmic reticulum as well as in plasma membranes in the liver and intestine.
      Title: Multidrug and toxic compound extrusion protein-1 (MATE1/SLC47A1) is a novel flavonoid transporter.
    7. [(11)C]Metformin may be useful as a PET probe to non-invasively study the in vivo function of hepatobiliary transport and drug-drug interactions, mediated by MATE1 in future clinical investigations.
      Title: The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo.
    8. Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.
      Title: Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.
    9. Homozygous MATE1 variant could be one of the risk factors for metformin-induced lactic acidosis.
      Title: Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.
    10. MATE1 mediates the efflux of cisplatin and is involved in cisplatin-induced nephrotoxicity.
      Title: Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyspecific organic cation:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyspecific organic cation:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables putrescine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thiamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in organic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    multidrug and toxin extrusion protein 1
    Names
    MATE-1
    mMATE-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026183.5 → NP_080459.2  multidrug and toxin extrusion protein 1

      See identical proteins and their annotated locations for NP_080459.2

      Status: VALIDATED

      Source sequence(s)
      AK009038, BB556514, BB661673, BY006577
      Consensus CDS
      CCDS24811.2
      UniProtKB/Swiss-Prot
      Q5SS45, Q8K0H1, Q9CQ64
      Related
      ENSMUSP00000010267.4, ENSMUST00000010267.10
      Conserved Domains (1) summary
      cd13132
      Location:34 → 468
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61234226..61269668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249188.3 → XP_011247490.1  multidrug and toxin extrusion protein 1 isoform X2

      Conserved Domains (1) summary
      cd13132
      Location:1 → 418
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    2. XM_006533993.2 → XP_006534056.1  multidrug and toxin extrusion protein 1 isoform X1

      Conserved Domains (1) summary
      cd13132
      Location:70 → 492
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    3. XM_036156909.1 → XP_036012802.1  multidrug and toxin extrusion protein 1 isoform X4

      Conserved Domains (1) summary
      cd13132
      Location:22 → 308
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    4. XM_036156910.1 → XP_036012803.1  multidrug and toxin extrusion protein 1 isoform X4

      Conserved Domains (1) summary
      cd13132
      Location:22 → 308
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    5. XM_011249189.4 → XP_011247491.1  multidrug and toxin extrusion protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011247491.1

      UniProtKB/Swiss-Prot
      Q8K0H1
      Conserved Domains (1) summary
      cd13132
      Location:40 → 326
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    6. XM_006533995.4 → XP_006534058.1  multidrug and toxin extrusion protein 1 isoform X5

      Conserved Domains (1) summary
      cd13132
      Location:1 → 280
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    RNA

    1. XR_003949493.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0H1.2 GenPept UniProtKB/Swiss-Prot:Q8K0H1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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