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    Decr1 2,4-dienoyl CoA reductase 1, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 67460, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Decr1provided by MGI
    Official Full Name
    2,4-dienoyl CoA reductase 1, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1914710
    See related
    Ensembl:ENSMUSG00000028223 AllianceGenome:MGI:1914710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Decr; Nadph; 1200012F07Rik
    Summary
    Predicted to enable 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Located in mitochondrion. Is expressed in axial skeleton. Orthologous to human DECR1 (2,4-dienoyl-CoA reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 41.1), liver E18 (RPKM 22.5) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Decr1 in Genome Data Viewer
    Location:
    4 A2; 4 6.66 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (15917240..15945377, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (15917240..15945377, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene calbindin 1 Neighboring gene predicted gene, 26148 Neighboring gene microRNA 6400 Neighboring gene nibrin Neighboring gene STARR-positive B cell enhancer ABC_E6155 Neighboring gene oxidative stress induced growth inhibitor family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and impairment of thermogenesis in mouse brown adipose tissue. Mäkelä AM, et al. Sci Rep, 2019 Aug 19. PMID 31427678, Free PMC Article
    2. Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis. Miinalainen IJ, et al. PLoS Genet, 2009 Jul. PMID 19578400, Free PMC Article
    3. Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. Zhou L, et al. FASEB J, 2017 Jan. PMID 27694478, Free PMC Article
    4. Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. Boyle MP, et al. J Comp Neurol, 2011 Aug 1. PMID 21491433
    5. Searching QTL by gene expression: analysis of diabesity. Brown AC, et al. BMC Genet, 2005 Mar 10. PMID 15760467, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fasted Decr(-/-) mice displayed increased serum acylcarnitines and unimpaired ketogenesis.
      Title: Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2,4-dienoyl-CoA reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
    Names
    2,4-dienoyl-CoA reductase, mitochondrial
    NP_080448.1
    XP_036020258.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026172.4 → NP_080448.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial precursor

      See identical proteins and their annotated locations for NP_080448.1

      Status: VALIDATED

      Source sequence(s)
      BC046972
      Consensus CDS
      CCDS17985.1
      UniProtKB/Swiss-Prot
      Q9CQ62, Q9DCI7
      UniProtKB/TrEMBL
      Q4FJK0
      Related
      ENSMUSP00000029877.9, ENSMUST00000029877.9
      Conserved Domains (2) summary
      PRK07677
      Location:59 → 303
      PRK07677; short chain dehydrogenase; Provisional
      cd05369
      Location:57 → 303
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      15917240..15945377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164365.1 → XP_036020258.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X1

      Conserved Domains (1) summary
      cd05369
      Location:7 → 253
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ62.1 GenPept UniProtKB/Swiss-Prot:Q9CQ62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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