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    Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 [ Mus musculus (house mouse) ]

    Gene ID: 67458, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ergic1provided by MGI
    Official Full Name
    endoplasmic reticulum-golgi intermediate compartment 1provided by MGI
    Primary source
    MGI:MGI:1914708
    See related
    Ensembl:ENSMUSG00000001576 AllianceGenome:MGI:1914708
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    maa-136; 1200007D18Rik
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment and nucleoplasm. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and membrane. Predicted to be integral component of Golgi membrane and integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in neurogenic-type arthrogryposis multiplex congenita-2. Orthologous to human ERGIC1 (endoplasmic reticulum-golgi intermediate compartment 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 90.1), subcutaneous fat pad adult (RPKM 78.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 13.34 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26779736..26875908)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26560762..26656934)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11632 Neighboring gene RIKEN cDNA 1700049J03 gene Neighboring gene predicted gene, 34606 Neighboring gene STARR-seq mESC enhancer starr_42128 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 41553 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit E Neighboring gene STARR-positive B cell enhancer ABC_E3193 Neighboring gene STARR-positive B cell enhancer ABC_E2474 Neighboring gene CREB3 regulatory factor Neighboring gene STARR-positive B cell enhancer ABC_E8660

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102406

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum-Golgi intermediate compartment protein 1
    Names
    ER-Golgi intermediate compartment 32 kDa protein
    ERGIC-32
    endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026170.3 → NP_080446.1  endoplasmic reticulum-Golgi intermediate compartment protein 1

      See identical proteins and their annotated locations for NP_080446.1

      Status: PROVISIONAL

      Source sequence(s)
      AC122252, CT025550
      Consensus CDS
      CCDS28553.1
      UniProtKB/Swiss-Prot
      Q9DC16
      UniProtKB/TrEMBL
      Q4FK22, Q69ZP5
      Related
      ENSMUSP00000132922.2, ENSMUST00000167662.8
      Conserved Domains (2) summary
      pfam07970
      Location:114 → 271
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:5 → 98
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26779736..26875908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524823.2 → XP_006524886.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X2

      UniProtKB/TrEMBL
      Q69ZP5
      Conserved Domains (2) summary
      pfam07970
      Location:119 → 286
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:22 → 113
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    2. XM_036160753.1 → XP_036016646.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X8

      Conserved Domains (1) summary
      pfam07970
      Location:1 → 126
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    3. XM_030250008.1 → XP_030105868.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A494BAK4, A0A494BAW5
      Related
      ENSMUSP00000158266.2, ENSMUST00000235915.2
      Conserved Domains (1) summary
      pfam07970
      Location:22 → 179
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    4. XM_030250010.1 → XP_030105870.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X6

      UniProtKB/TrEMBL
      F6SLP4
      Related
      ENSMUSP00000127158.3, ENSMUST00000167070.3
      Conserved Domains (1) summary
      pfam07970
      Location:12 → 162
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    5. XM_036160752.1 → XP_036016645.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A494BAK4, A0A494BAW5
      Conserved Domains (1) summary
      pfam07970
      Location:22 → 179
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    6. XM_030250005.2 → XP_030105865.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X4

      Conserved Domains (1) summary
      pfam07970
      Location:12 → 162
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    7. XM_036160750.1 → XP_036016643.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X1

      Conserved Domains (2) summary
      pfam07970
      Location:114 → 254
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:8 → 98
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    8. XM_036160751.1 → XP_036016644.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X3

      UniProtKB/TrEMBL
      Q69ZP5
      Conserved Domains (2) summary
      pfam07970
      Location:114 → 271
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:8 → 98
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    9. XM_006524824.1 → XP_006524887.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X7

      See identical proteins and their annotated locations for XP_006524887.1

      Related
      ENSMUST00000236163.2
      Conserved Domains (1) summary
      pfam07970
      Location:1 → 109
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DC16.1 GenPept UniProtKB/Swiss-Prot:Q9DC16

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