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    Nts neurotensin [ Mus musculus (house mouse) ]

    Gene ID: 67405, updated on 23-Apr-2024

    Summary

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    Official Symbol
    Ntsprovided by MGI
    Official Full Name
    neurotensinprovided by MGI
    Primary source
    MGI:MGI:1328351
    See related
    Ensembl:ENSMUSG00000019890 AllianceGenome:MGI:1328351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NN; NT; NT/N; NTS1; NMN-125; 5033428E16Rik
    Summary
    Predicted to enable neuropeptide receptor binding activity and receptor ligand activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; neuropeptide signaling pathway; and visual learning. Predicted to be located in intracellular membrane-bounded organelle and neuronal cell body. Predicted to be active in axon terminus. Is expressed in central nervous system; genitourinary system; heart ventricle; jaw; and retina. Orthologous to human NTS (neurotensin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 17.8), large intestine adult (RPKM 7.5) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 D1; 10 53.56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (102317617..102326294, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (102481756..102490418, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27741 Neighboring gene predicted gene, 26278 Neighboring gene MGAT4 family, member C Neighboring gene microRNA 3059 Neighboring gene STARR-seq mESC enhancer starr_27742 Neighboring gene STARR-seq mESC enhancer starr_27743 Neighboring gene STARR-seq mESC enhancer starr_27744 Neighboring gene STARR-seq mESC enhancer starr_27745 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 Neighboring gene predicted gene 5175

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin. Liu C, et al. J Hepatol, 2023 Jul. PMID 36567053
    2. Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovary†. Shrestha K, et al. Biol Reprod, 2023 Jan 14. PMID 36345168, Free PMC Article
    3. Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling. Tschumi CW, et al. J Neurosci, 2022 Aug 10. PMID 35794014, Free PMC Article
    4. Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord. Zhang MM, et al. Front Neural Circuits, 2021. PMID 35002634, Free PMC Article
    5. Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons. Li B, et al. Proc Natl Acad Sci U S A, 2020 Jul 21. PMID 32631999, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neurotensin counteracts hair growth inhibition induced by chronic restraint stress.
      Title: Neurotensin counteracts hair growth inhibition induced by chronic restraint stress.
    2. Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice.
      Title: Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice.
    3. Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin.
      Title: Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin.
    4. Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovarydagger.
      Title: Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovary†.
    5. Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling.
      Title: Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling.
    6. Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.
      Title: Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.
    7. Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord.
      Title: Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord.
    8. Effect of neurotensin on cultured mouse preimplantation embryos.
      Title: Effect of neurotensin on cultured mouse preimplantation embryos.
    9. Study found that locally-released neurotensin (NT) and dynorphin (Dyn) antagonistically regulated central amygdala (CeA) inhibitory inputs onto oval bed nucleus of the stria terminalis (ovBNST) neurons. NT and Dyn respectively increased and decreased CeA-toovBNST inhibitory inputs through NT receptor 1 and kappa opioid receptor. NT and Dyn mRNAs were highly co-localized in ovBNST neurons.
      Title: Neurotensin and dynorphin Bi-Directionally modulate CeA inhibition of oval BNST neurons in male mice.
    10. Study reveals multiple populations of neurotensin neurons that provide direct afferents to the ventral tegmental area and which may regulate specific aspects of motivated behavior.
      Title: Determination of neurotensin projections to the ventral tegmental area in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neuropeptide hormone activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neurotensin/neuromedin N
    Names
    neuromedin N

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429471.1 → NP_001416400.1  neurotensin/neuromedin N isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131720

    2. NM_024435.3 → NP_077755.1  neurotensin/neuromedin N isoform 1 precursor

      See identical proteins and their annotated locations for NP_077755.1

      Status: VALIDATED

      Source sequence(s)
      AC131720
      Consensus CDS
      CCDS24154.1
      UniProtKB/Swiss-Prot
      Q9D3P9
      Related
      ENSMUSP00000020040.4, ENSMUST00000020040.5
      Conserved Domains (1) summary
      pfam07421
      Location:6 → 168
      Pro-NT_NN; Neurotensin/neuromedin N precursor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      102317617..102326294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513992.4 → XP_006514055.1  neurotensin/neuromedin N isoform X1

      Conserved Domains (1) summary
      pfam07421
      Location:1 → 129
      Pro-NT_NN; Neurotensin/neuromedin N precursor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3P9.1 GenPept UniProtKB/Swiss-Prot:Q9D3P9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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