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    Dedd2 death effector domain-containing DNA binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 67379, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dedd2provided by MGI
    Official Full Name
    death effector domain-containing DNA binding protein 2provided by MGI
    Primary source
    MGI:MGI:1914629
    See related
    Ensembl:ENSMUSG00000054499 AllianceGenome:MGI:1914629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FLAME-3; 2410050E11Rik
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in apoptotic nuclear changes; extrinsic apoptotic signaling pathway via death domain receptors; and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Orthologous to human DEDD2 (death effector domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 41.3), small intestine adult (RPKM 39.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A3; 7 13.73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24899337..24920035, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25199912..25220614, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene POU domain, class 2, transcription factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E3704 Neighboring gene microRNA 6537 Neighboring gene STARR-seq mESC enhancer starr_18291 Neighboring gene STARR-positive B cell enhancer ABC_E2225 Neighboring gene STARR-positive B cell enhancer ABC_E6522 Neighboring gene STARR-positive B cell enhancer ABC_E3705 Neighboring gene RIKEN cDNA D930028M14 gene Neighboring gene STARR-seq mESC enhancer starr_18292 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25990365-25990647 Neighboring gene STARR-seq mESC enhancer starr_18294 Neighboring gene STARR-positive B cell enhancer ABC_E868 Neighboring gene STARR-positive B cell enhancer ABC_E1724 Neighboring gene RIKEN cDNA 9130221H12 gene Neighboring gene microRNA 7048 Neighboring gene zinc finger protein 526 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26024418-26024601 Neighboring gene glycogen synthase kinase 3 alpha Neighboring gene STARR-positive B cell enhancer ABC_E3706 Neighboring gene Ets2 repressor factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The death effector domain protein family. Barnhart BC, et al. Oncogene, 2003 Nov 24. PMID 14634625
    2. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Alcivar A, et al. Oncogene, 2003 Jan 16. PMID 12527898
    3. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Zhan Y, et al. Cell Death Differ, 2002 Apr. PMID 11965497
    4. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, et al. Genome Res, 2003 Jun. PMID 12819136, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic nuclear changes ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding death effector domain-containing protein 2
    Names
    DED-containing protein FLAME-3
    FADD-like anti-apoptotic molecule 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207677.3 → NP_997560.3  DNA-binding death effector domain-containing protein 2

      See identical proteins and their annotated locations for NP_997560.3

      Status: VALIDATED

      Source sequence(s)
      BC092250
      Consensus CDS
      CCDS20973.1
      UniProtKB/Swiss-Prot
      Q569Y9, Q8JZV1, Q8QZV0
      Related
      ENSMUSP00000049763.6, ENSMUST00000058702.7
      Conserved Domains (1) summary
      cl14633
      Location:14 → 118
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24899337..24920035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242925.2 → XP_030098785.1  DNA-binding death effector domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q569Y9, Q8JZV1, Q8QZV0
      Conserved Domains (1) summary
      cl14633
      Location:14 → 118
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. XM_036153381.1 → XP_036009274.1  DNA-binding death effector domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q569Y9, Q8JZV1, Q8QZV0
      Related
      ENSMUST00000206750.2
      Conserved Domains (1) summary
      cl14633
      Location:14 → 118
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. XR_003946545.2 RNA Sequence

    2. XR_391094.3 RNA Sequence

    3. XR_004934172.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026117.2: Suppressed sequence

      Description
      NM_026117.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZV0.1 GenPept UniProtKB/Swiss-Prot:Q8QZV0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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