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    Zfp606 zinc finger protein 606 [ Mus musculus (house mouse) ]

    Gene ID: 67370, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp606provided by MGI
    Official Full Name
    zinc finger protein 606provided by MGI
    Primary source
    MGI:MGI:1914620
    See related
    Ensembl:ENSMUSG00000030386 AllianceGenome:MGI:1914620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410022M24Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF606 (zinc finger protein 606). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 3.9), CNS E11.5 (RPKM 3.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A1; 7 7.52 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12212208..12230162)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12478280..12496235)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 551 Neighboring gene vomeronasal 2, receptor, pseudogene 53 Neighboring gene STARR-seq mESC enhancer starr_18051 Neighboring gene RIKEN cDNA 2900092C05 gene Neighboring gene STARR-seq mESC enhancer starr_18052 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18053 Neighboring gene vomeronasal 2, receptor 53 Neighboring gene PC4 and SFRS1 interacting protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 606

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039951.2 → NP_001035040.1  zinc finger protein 606 isoform 2

      See identical proteins and their annotated locations for NP_001035040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and lacks several coding exons, compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK032301, AK165095, BY278345
      Consensus CDS
      CCDS85215.1
      UniProtKB/TrEMBL
      Q2TAX9
      Related
      ENSMUSP00000147558.2, ENSMUST00000123589.8

    2. NM_001310620.1 → NP_001297549.1  zinc finger protein 606 isoform 3

      See identical proteins and their annotated locations for NP_001297549.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon. This variant represents translation initiation at an alternate AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (3) that has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC139131, AK139269, AK143200
      Consensus CDS
      CCDS80663.1
      UniProtKB/TrEMBL
      Q69Z88
      Conserved Domains (5) summary
      smart00349
      Location:5 → 65
      KRAB; krueppel associated box
      COG5048
      Location:328 → 734
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:403 → 423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 44
      KRAB; KRAB box
      pfam13465
      Location:583 → 608
      zf-H2C2_2; Zinc-finger double domain

    3. NM_026112.4 → NP_080388.2  zinc finger protein 606 isoform 1

      See identical proteins and their annotated locations for NP_080388.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK139269, AK143200
      Consensus CDS
      CCDS20810.1
      UniProtKB/TrEMBL
      Q7TSV0
      Related
      ENSMUSP00000096421.4, ENSMUST00000098822.10
      Conserved Domains (6) summary
      smart00349
      Location:63 → 123
      KRAB; krueppel associated box
      COG5048
      Location:386 → 792
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:739 → 761
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:63 → 102
      KRAB; KRAB box
      pfam13465
      Location:641 → 666
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12212208..12230162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540320.4 → XP_006540383.1  zinc finger protein 606 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:24 → 84
      KRAB; krueppel associated box
      COG5048
      Location:347 → 753
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:422 → 442
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_881784.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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