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    Tmco5 transmembrane and coiled-coil domains 5 [ Mus musculus (house mouse) ]

    Gene ID: 67356, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmco5provided by MGI
    Official Full Name
    transmembrane and coiled-coil domains 5provided by MGI
    Primary source
    MGI:MGI:1914606
    See related
    Ensembl:ENSMUSG00000027355 AllianceGenome:MGI:1914606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmco5a; 1700095F04Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in spinal cord and testis. Orthologous to human TMCO5A (transmembrane and coiled-coil domains 5A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 31.5) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E5; 2 59.03 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (116709174..116722987)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (116878693..116892506)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAB5B, member RAS oncogene family pseudogene Neighboring gene STARR-seq mESC enhancer starr_05435 Neighboring gene predicted gene 13990 Neighboring gene RIKEN cDNA D330050G23 gene Neighboring gene predicted gene, 46758 Neighboring gene STARR-seq mESC enhancer starr_05436 Neighboring gene predicted gene, 25514

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse TMCO5 is localized to the manchette microtubules involved in vesicle transfer in the elongating spermatids. Yamase K, et al. PLoS One, 2019. PMID 31393949, Free PMC Article
    2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tmco5 may have a role in vesicle transport along the manchette.
      Title: Mouse TMCO5 is localized to the manchette microtubules involved in vesicle transfer in the elongating spermatids.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domain-containing protein 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355572.2 → NP_001342501.1  transmembrane and coiled-coil domain-containing protein 5A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL845318
      UniProtKB/TrEMBL
      Z4YLS6
      Conserved Domains (1) summary
      pfam14992
      Location:30 → 282
      TMCO5; TMCO5 family

    2. NM_001379337.1 → NP_001366266.1  transmembrane and coiled-coil domain-containing protein 5A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 1, encodes the longer isoform (1).
      Source sequence(s)
      AL845318
      UniProtKB/Swiss-Prot
      A2ARB1, Q9CVN5, Q9D9D5
      UniProtKB/TrEMBL
      Z4YLS6
      Conserved Domains (1) summary
      pfam14992
      Location:28 → 302
      TMCO5; TMCO5 family

    3. NM_026104.5 → NP_080380.1  transmembrane and coiled-coil domain-containing protein 5A isoform 1

      See identical proteins and their annotated locations for NP_080380.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL845318
      Consensus CDS
      CCDS16569.1
      UniProtKB/Swiss-Prot
      A2ARB1, Q9CVN5, Q9D9D5
      UniProtKB/TrEMBL
      Z4YLS6
      Related
      ENSMUSP00000028834.3, ENSMUST00000028834.3
      Conserved Domains (1) summary
      pfam14992
      Location:28 → 302
      TMCO5; TMCO5 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      116709174..116722987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239746.3 → XP_011238048.1  transmembrane and coiled-coil domain-containing protein 5A isoform X1

      Conserved Domains (1) summary
      pfam14992
      Location:83 → 355
      TMCO5; TMCO5 family

    2. XM_011239747.3 → XP_011238049.1  transmembrane and coiled-coil domain-containing protein 5A isoform X2

      Conserved Domains (1) summary
      pfam14992
      Location:83 → 345
      TMCO5; TMCO5 family

    3. XM_011239748.3 → XP_011238050.1  transmembrane and coiled-coil domain-containing protein 5A isoform X3

      Conserved Domains (1) summary
      pfam14992
      Location:83 → 335
      TMCO5; TMCO5 family

    4. XM_011239749.3 → XP_011238051.1  transmembrane and coiled-coil domain-containing protein 5A isoform X4

      Conserved Domains (1) summary
      pfam14992
      Location:83 → 216
      TMCO5; TMCO5 family

    RNA

    1. XR_004940710.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9D5.1 GenPept UniProtKB/Swiss-Prot:Q9D9D5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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