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    Herc4 hect domain and RLD 4 [ Mus musculus (house mouse) ]

    Gene ID: 67345, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Herc4provided by MGI
    Official Full Name
    hect domain and RLD 4provided by MGI
    Primary source
    MGI:MGI:1914595
    See related
    Ensembl:ENSMUSG00000020064 AllianceGenome:MGI:1914595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1593; 1700056O17Rik; 4921531D01Rik; 9530080M15Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in spermatogenesis. Predicted to be located in cytosol and fibrillar center. Orthologous to human HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 13.5), bladder adult (RPKM 8.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Herc4 in Genome Data Viewer
    Location:
    10 B4; 10 32.56 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63079122..63153660)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63243751..63317881)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26919 Neighboring gene atonal bHLH transcription factor 7 Neighboring gene myopalladin Neighboring gene STARR-seq mESC enhancer starr_26921 Neighboring gene STARR-seq mESC enhancer starr_26922 Neighboring gene STARR-seq mESC enhancer starr_26924 Neighboring gene STARR-seq mESC enhancer starr_26926 Neighboring gene RIKEN cDNA 1700120B22 gene Neighboring gene predicted gene, 51767 Neighboring gene Sirt1 promoter region Neighboring gene sirtuin 1 Neighboring gene STARR-seq mESC enhancer starr_26931 Neighboring gene STARR-seq mESC enhancer starr_26932 Neighboring gene STARR-positive B cell enhancer ABC_E5142 Neighboring gene DnaJ heat shock protein family (Hsp40) member C12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice. Zhang Z, et al. Blood, 2016 Mar 31. PMID 26825710
    2. Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility. Rodriguez CI, et al. Dev Biol, 2007 Dec 15. PMID 17967448
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi F, et al. Front Endocrinol (Lausanne), 2018. PMID 30713523, Free PMC Article
    5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HERC4 plays an important role in Multiple myeloma progression.
      Title: The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.
    2. The E3 ubiquitin ligase Herc4, though ubiquitously expressed in all tissues, is most highly expressed in the testis, specifically during spermiogenesis
      Title: Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2)  1 citation
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HERC4
    Names
    HECT domain and RCC1-like domain-containing protein 4
    HECT-type E3 ubiquitin transferase HERC4
    NP_001346413.1
    NP_080377.2
    NP_084390.1
    XP_006514049.1
    XP_006514052.1
    XP_006514053.1
    XP_030101093.1
    XP_030101094.1
    XP_036011855.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359484.1 → NP_001346413.1  probable E3 ubiquitin-protein ligase HERC4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the central coding region and lacks an in-frame exon in the 3' coding region, compared to variant 1. It encodes a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AA253833, AC155909, AK019546, BM249989, BU611209, CA322829, CN713165
      Conserved Domains (2) summary
      cd00078
      Location:580 → 926
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl27697
      Location:2 → 344
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    2. NM_026101.4 → NP_080377.2  probable E3 ubiquitin-protein ligase HERC4 isoform 2

      See identical proteins and their annotated locations for NP_080377.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AK147723, BM249989, BQ899503
      Consensus CDS
      CCDS23897.1
      UniProtKB/Swiss-Prot
      Q6PAV2
      Related
      ENSMUSP00000020258.9, ENSMUST00000020258.10
      Conserved Domains (3) summary
      smart00119
      Location:727 → 1046
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:701 → 1047
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:208 → 257
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    3. NM_030114.2 → NP_084390.1  probable E3 ubiquitin-protein ligase HERC4 isoform 1

      See identical proteins and their annotated locations for NP_084390.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK143111, AK147723, BM249989, BQ899503
      Consensus CDS
      CCDS88014.1
      UniProtKB/Swiss-Prot
      Q3UL34, Q3UPX2, Q6PAV2, Q810A0, Q811C9, Q8R315, Q9D797
      Related
      ENSMUSP00000151886.2, ENSMUST00000219577.2
      Conserved Domains (3) summary
      smart00119
      Location:735 → 1054
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:709 → 1055
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:208 → 257
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      63079122..63153660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513989.4 → XP_006514052.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

      Conserved Domains (2) summary
      cd00078
      Location:454 → 800
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:5 → 53
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    2. XM_006513986.4 → XP_006514049.1  probable E3 ubiquitin-protein ligase HERC4 isoform X2

      Conserved Domains (2) summary
      COG5184
      Location:2 → 344
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:588 → 934
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    3. XM_030245233.1 → XP_030101093.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

      Conserved Domains (2) summary
      COG5184
      Location:12 → 268
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:639 → 985
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    4. XM_030245234.1 → XP_030101094.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

      Conserved Domains (2) summary
      cd00078
      Location:454 → 800
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:5 → 53
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    5. XM_036155962.1 → XP_036011855.1  probable E3 ubiquitin-protein ligase HERC4 isoform X5

      Conserved Domains (1) summary
      cd00078
      Location:250 → 596
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    6. XM_006513990.3 → XP_006514053.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

      Conserved Domains (2) summary
      cd00078
      Location:446 → 792
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:5 → 53
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RNA

    1. XR_003948785.2 RNA Sequence

    2. XR_380431.5 RNA Sequence

    3. XR_003948784.2 RNA Sequence

    4. XR_003948786.2 RNA Sequence

    5. XR_004936261.1 RNA Sequence

    6. XR_004936260.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PAV2.2 GenPept UniProtKB/Swiss-Prot:Q6PAV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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