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    Rab3c RAB3C, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 67295, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rab3cprovided by MGI
    Official Full Name
    RAB3C, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1914545
    See related
    Ensembl:ENSMUSG00000021700 AllianceGenome:MGI:1914545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700062I01Rik; 3110015B08Rik; 3110037E15Rik
    Summary
    Enables GTP-dependent protein binding activity. Acts upstream of or within regulation of exocytosis. Located in synaptic vesicle. Is expressed in several structures, including adrenal gland; alimentary system; brain; sensory organ; and skeleton. Orthologous to human RAB3C (RAB3C, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 16.0), frontal lobe adult (RPKM 15.2) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 D2.1; 13 61.19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (110190721..110417530, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (110054187..110280996, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4D, cAMP specific Neighboring gene STARR-positive B cell enhancer ABC_E9403 Neighboring gene STARR-positive B cell enhancer mm9_chr13:110712491-110712792 Neighboring gene STARR-seq mESC enhancer starr_35632 Neighboring gene microRNA 1904 Neighboring gene STARR-seq mESC enhancer starr_35633 Neighboring gene STARR-seq mESC enhancer starr_35634 Neighboring gene predicted gene, 32881 Neighboring gene STARR-seq mESC enhancer starr_35636 Neighboring gene STARR-seq mESC enhancer starr_35637 Neighboring gene predicted gene, 53813 Neighboring gene predicted gene, 41057 Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene Grb2-binding adaptor, transmembrane

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of the mouse homologue of Rab3c. Pavlos NJ, et al. J Mol Endocrinol, 2001 Aug. PMID 11573517
    2. Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis. Bubier JA, et al. Front Neurosci, 2020. PMID 32742255, Free PMC Article
    3. A unique residue in rab3c determines the interaction with novel binding protein Zwint-1. van Vlijmen T, et al. FEBS Lett, 2008 Aug 20. PMID 18625232
    4. Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Schonn JS, et al. Traffic, 2010 Nov. PMID 20716109
    5. Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. Schlüter OM, et al. J Neurosci, 2006 Jan 25. PMID 16436611, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab3b/3c-positive recycling vesicles are involved in and may constitute one of the recycling compartments in exogenous antigen cross-presentation.
      Title: The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells.
    2. Zwint-1 is a rab3 specific binding protein that bound preferentially to rab3c.
      Title: A unique residue in rab3c determines the interaction with novel binding protein Zwint-1.
    3. Rab3-induced modifications to primed vesicles causes a transient increase in the transduction efficacy of synaptic action potential trains and optimizes the encoding of synaptic information at an intermediate spike frequency range.
      Title: Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124069

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin V binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-3C
    Names
    small GTP-binding protein Rab3C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360099.1 → NP_001347028.1  ras-related protein Rab-3C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124235, AC154470, CT025643
      Consensus CDS
      CCDS88528.1
      UniProtKB/TrEMBL
      A0A286YDR2, Q3TU26
      Related
      ENSMUSP00000153347.2, ENSMUST00000223922.2
      Conserved Domains (1) summary
      cd01865
      Location:28 → 192
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    2. NM_023852.5 → NP_076341.1  ras-related protein Rab-3C isoform 1

      See identical proteins and their annotated locations for NP_076341.1

      Status: VALIDATED

      Source sequence(s)
      AK164316, CJ123980, CT025643
      Consensus CDS
      CCDS26764.1
      UniProtKB/Swiss-Prot
      P62823, Q62858, Q62974, Q63482, Q9CXQ1
      UniProtKB/TrEMBL
      Q3TU26, Q542T7
      Related
      ENSMUSP00000132945.2, ENSMUST00000167824.3
      Conserved Domains (1) summary
      cd01865
      Location:30 → 194
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      110190721..110417530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517741.4 → XP_006517804.1  ras-related protein Rab-3C isoform X1

      UniProtKB/TrEMBL
      Q3TU26
      Conserved Domains (1) summary
      cd01865
      Location:22 → 186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    2. XM_006517742.5 → XP_006517805.1  ras-related protein Rab-3C isoform X2

      See identical proteins and their annotated locations for XP_006517805.1

      UniProtKB/TrEMBL
      Q9CXS2
      Related
      ENSMUSP00000153136.2, ENSMUST00000224180.2
      Conserved Domains (1) summary
      cl38936
      Location:30 → 166
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62823.1 GenPept UniProtKB/Swiss-Prot:P62823

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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