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    Ift22 intraflagellar transport 22 [ Mus musculus (house mouse) ]

    Gene ID: 67286, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ift22provided by MGI
    Official Full Name
    intraflagellar transport 22provided by MGI
    Primary source
    MGI:MGI:1914536
    See related
    Ensembl:ENSMUSG00000007987 AllianceGenome:MGI:1914536
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rabl5; 3110017O03Rik
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to act upstream of or within intraciliary transport. Located in centrosome and cilium. Part of intraciliary transport particle B. Is expressed in several structures, including adrenal gland; genitourinary system; gut; nervous system; and respiratory system. Orthologous to human IFT22 (intraflagellar transport 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 30.6), frontal lobe adult (RPKM 11.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G2; 5 76.03 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136937004..136943363)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136908150..136914509)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene collagen, type XXVI, alpha 1 Neighboring gene VISTA enhancer mm1626 Neighboring gene predicted gene 20485 Neighboring gene predicted gene 43649 Neighboring gene RIKEN cDNA 4933404O12 gene Neighboring gene STARR-seq mESC enhancer starr_14629 Neighboring gene STARR-seq mESC enhancer starr_14631 Neighboring gene STARR-positive B cell enhancer ABC_E10358 Neighboring gene fission, mitochondrial 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Liew GM, et al. Dev Cell, 2014 Nov 10. PMID 25443296, Free PMC Article
    2. TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Ishikawa H, et al. Elife, 2014 Jan 1. PMID 24596149, Free PMC Article
    3. Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex. Katoh Y, et al. J Biol Chem, 2016 May 20. PMID 26980730, Free PMC Article
    4. Characterization of mouse IFT complex B. Follit JA, et al. Cell Motil Cytoskeleton, 2009 Aug. PMID 19253336, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary anterograde transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within intraciliary transport IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cilium TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport protein 22 homolog
    Names
    RAB, member of RAS oncogene family-like 5
    rab-like protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026073.3 → NP_080349.1  intraflagellar transport protein 22 homolog

      See identical proteins and their annotated locations for NP_080349.1

      Status: PROVISIONAL

      Source sequence(s)
      AC147987
      Consensus CDS
      CCDS19756.1
      UniProtKB/Swiss-Prot
      Q9DAI2
      UniProtKB/TrEMBL
      A0A0G2JF44
      Related
      ENSMUSP00000143488.2, ENSMUST00000200157.5
      Conserved Domains (2) summary
      COG1100
      Location:1 → 104
      Gem1; GTPase SAR1 family domain [General function prediction only]
      cl21455
      Location:5 → 124
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      136937004..136943363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240905.4 → XP_011239207.1  intraflagellar transport protein 22 homolog isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAI2.1 GenPept UniProtKB/Swiss-Prot:Q9DAI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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