Uqcc2 ubiquinol-cytochrome c reductase complex assembly factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uqcc2provided by MGI
Official Full Name: ubiquinol-cytochrome c reductase complex assembly factor 2provided by MGI
Primary source: MGI:MGI:1914517
See related: Ensembl:ENSMUSG00000024208 AllianceGenome:MGI:1914517
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: M19; Cbp6; Mnf1; 2900010M23Rik
Summary: Involved in regulation of insulin secretion; regulation of oxidative phosphorylation; and regulation of skeletal muscle cell differentiation. Located in mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial matrix. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 7. Orthologous to human UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 176.8), cortex adult (RPKM 42.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 13.75 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (27341639..27352865, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (27122665..27133891, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The function of M19, a novel mitochondrial nucleoid protein, is characterized in muscle and pancreatic beta-cells.
Title: M19 modulates skeletal muscle differentiation and insulin secretion in pancreatic β-cells through modulation of respiratory chain activity.
M19 associates with the nucleoid and likely regulates the organization and metabolism of mtDNA.
Title: Association of a novel mitochondrial protein M19 with mitochondrial nucleoids.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI790199 (e-PCR)
- UniSTS:165662

NoName (e-PCR)
- UniSTS:237610

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in mitochondrial respiratory chain complex III assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex III assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of oxidative phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquinol-cytochrome c reductase complex assembly factor 2

Names: mitochondrial nucleoid factor 1; mitochondrial protein M19

NP_001351873.1

EC 2.7.4.21

NP_080339.1

EC 2.7.4.21

XP_006524884.1

EC 2.7.4.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.