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    Cinp cyclin dependent kinase 2 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 67236, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cinpprovided by MGI
    Official Full Name
    cyclin dependent kinase 2 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1914486
    See related
    Ensembl:ENSMUSG00000021276 AllianceGenome:MGI:1914486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810047K05Rik; 2810452K22Rik
    Summary
    Predicted to act upstream of or within DNA repair; DNA replication; and cell division. Predicted to be located in nucleus. Is expressed in axial musculature; ganglia; incisor; medulla oblongata basal plate mantle layer; and submandibular gland primordium. Orthologous to human CINP (cyclin dependent kinase 2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 13.4), CNS E18 (RPKM 12.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 F1; 12 60.85 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110839044..110855579, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110872610..110889145, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4044 Neighboring gene nuclear encoded tRNA isoleucine 6 (anticodon AAT) Neighboring gene zinc finger protein 839 Neighboring gene mitochondrial pyruvate carrier 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1157 Neighboring gene tectonin beta-propeller repeat containing 2 Neighboring gene ribosomal protein S19, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_33311 Neighboring gene ankyrin repeat domain 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables preribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 2-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026048.4 → NP_080324.1  cyclin-dependent kinase 2-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_080324.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. It encodes isoform 1.
      Source sequence(s)
      AC101875, AK076126, BB761424
      Consensus CDS
      CCDS36561.1
      UniProtKB/Swiss-Prot
      Q8C063, Q9D0V8, Q9D8P9
      Related
      ENSMUSP00000035245.9, ENSMUST00000043716.9

    2. NM_027223.1 → NP_081499.1  cyclin-dependent kinase 2-interacting protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is longer than isoform 1.
      Source sequence(s)
      AC101875
      Consensus CDS
      CCDS88405.1
      UniProtKB/TrEMBL
      A0A1Y7VN75
      Related
      ENSMUSP00000152272.2, ENSMUST00000220607.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      110839044..110855579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0V8.1 GenPept UniProtKB/Swiss-Prot:Q9D0V8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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