Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmc6provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, ATPase, 6provided by MGI
Primary source: MGI:MGI:1914339
See related: Ensembl:ENSMUSG00000021832 AllianceGenome:MGI:1914339
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2300001E01Rik
Summary: Predicted to enable identical protein binding activity and proteasome-activating activity. Predicted to be involved in positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of inclusion body assembly; and ubiquitin-dependent ERAD pathway. Part of proteasome accessory complex. Is expressed in several structures, including brain; genitourinary system; gut; integumental system; and vascular system. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 59.8), liver E14 (RPKM 50.8) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 22.89 cM; 14 C1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (45567285..45587150)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (45329823..45349074)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSMC6 induces immune cell infiltration and inflammatory response to aggravate primary Sjogren's syndrome.
Title: PSMC6 induces immune cell infiltration and inflammatory response to aggravate primary Sjögren's syndrome.
PSMC6 promotes osteoblast apoptosis through inhibiting PI3K/AKT signaling pathway activation in ovariectomy-induced osteoporosis mouse model.
Title: PSMC6 promotes osteoblast apoptosis through inhibiting PI3K/AKT signaling pathway activation in ovariectomy-induced osteoporosis mouse model.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68060 (e-PCR)
- UniSTS:86604

AI451058 (e-PCR)
- UniSTS:185999

NoName (e-PCR)
- UniSTS:492522

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of inclusion body assembly	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytosolic proteasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic proteasome complex	ISO Inferred from Sequence Orthology more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome accessory complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome regulatory subunit 10B

Names: 26S protease regulatory subunit 10B; 26S protease regulatory subunit S10B; 26S proteasome AAA-ATPase subunit RPT4; proteasome 26S subunit ATPase 6; proteasome subunit p42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416015.1 → NP_001402944.1 26S proteasome regulatory subunit 10B isoform 2

Status: VALIDATED

Source sequence(s)

AC154575
NM_025959.4 → NP_080235.2 26S proteasome regulatory subunit 10B isoform 1

See identical proteins and their annotated locations for NP_080235.2

Status: VALIDATED

Source sequence(s)

AC154575

Consensus CDS

CCDS26974.1

UniProtKB/Swiss-Prot

P62334, Q3TKK1, Q810A6, Q9CXH9

UniProtKB/TrEMBL

Q14AQ1

Related

ENSMUSP00000022380.8, ENSMUST00000022380.9

Conserved Domains (1) summary

COG1222
Location:4 → 387

RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]