Rps6ka6 ribosomal protein S6 kinase polypeptide 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps6ka6provided by MGI
Official Full Name: ribosomal protein S6 kinase polypeptide 6provided by MGI
Primary source: MGI:MGI:1914321
See related: Ensembl:ENSMUSG00000025665 AllianceGenome:MGI:1914321
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RSK4; S6K-alpha-6; 2610524K04Rik
Summary: Predicted to enable ribosomal protein S6 kinase activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of embryonic development; and negative regulation of mesoderm development. Predicted to be located in fibrillar center and mitochondrion. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including genitourinary system; nervous system; nose; respiratory system; and thymus primordium. Orthologous to human RPS6KA6 (ribosomal protein S6 kinase A6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 15.3), CNS E11.5 (RPKM 4.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: X E1; X 48.2 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (110297534..110447794, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (111387837..111538097, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAF4 knockdown significantly inhibited proliferation, invasion and metastasis in the xenograft nude mouse model, possibly involving in the interaction with RSK4.
Title: Down-regulation of TRAF4 targeting RSK4 inhibits proliferation, invasion and metastasis in breast cancer xenografts.
Rsk4 inhibits the transcriptional activation of specific targets of receptor tyrosine kinase signaling as well as the activation of ERK
Title: Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (3)

General gene information

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Markers

Rps6ka6 (e-PCR), detects polymorphism
- UniSTS:527525

NoName (e-PCR)
- UniSTS:238072

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of embryonic development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mesoderm development	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-6

NP_001361636.2

EC 2.7.11.1

NP_001385703.1

EC 2.7.11.1

NP_080225.2

EC 2.7.11.1

XP_006528463.1

EC 2.7.11.1

XP_006528464.1

EC 2.7.11.1

XP_006528465.1

EC 2.7.11.1

XP_006528466.1

EC 2.7.11.1

XP_011246008.1

EC 2.7.11.1

XP_011246009.1

EC 2.7.11.1

XP_030107348.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374707.3 → NP_001361636.2 ribosomal protein S6 kinase alpha-6 isoform 2

Status: VALIDATED

Source sequence(s)

CR392009

UniProtKB/TrEMBL

A2CEE7

Related

ENSMUSP00000094073.5, ENSMUST00000096348.10
NM_001398774.1 → NP_001385703.1 ribosomal protein S6 kinase alpha-6 isoform 3

Status: VALIDATED

Source sequence(s)

CR392009

UniProtKB/TrEMBL

E9PUP0

Related

ENSMUSP00000109055.4, ENSMUST00000113428.9
NM_025949.3 → NP_080225.2 ribosomal protein S6 kinase alpha-6 isoform 1

See identical proteins and their annotated locations for NP_080225.2

Status: VALIDATED

Source sequence(s)

AK012150, AK049349, BC054113, BY096109, CR392009

Consensus CDS

CCDS30356.1

UniProtKB/Swiss-Prot

Q7TPS0, Q8BWZ2, Q9CUR6

UniProtKB/TrEMBL

B1B0X3, E9QK39

Related

ENSMUSP00000115975.3, ENSMUST00000123951.9

Conserved Domains (2) summary

cd05582
Location:193 → 507

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:542 → 828

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

110297534..110447794 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247706.4 → XP_011246008.1 ribosomal protein S6 kinase alpha-6 isoform X4

UniProtKB/Swiss-Prot

Q7TPS0, Q8BWZ2, Q9CUR6

Conserved Domains (2) summary

cd05582
Location:109 → 423

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:458 → 744

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
XM_006528403.4 → XP_006528466.1 ribosomal protein S6 kinase alpha-6 isoform X3

UniProtKB/TrEMBL

A2CEE5

Conserved Domains (2) summary

cd05582
Location:172 → 486

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:521 → 807

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
XM_006528402.4 → XP_006528465.1 ribosomal protein S6 kinase alpha-6 isoform X2

UniProtKB/Swiss-Prot

Q7TPS0, Q8BWZ2, Q9CUR6

Conserved Domains (2) summary

cd05582
Location:193 → 507

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:542 → 823

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
XM_006528401.5 → XP_006528464.1 ribosomal protein S6 kinase alpha-6 isoform X1

See identical proteins and their annotated locations for XP_006528464.1

UniProtKB/Swiss-Prot

Q7TPS0, Q8BWZ2, Q9CUR6

UniProtKB/TrEMBL

B1B0X3, E9QK39

Conserved Domains (2) summary

cd05582
Location:193 → 507

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:542 → 828

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
XM_006528400.5 → XP_006528463.1 ribosomal protein S6 kinase alpha-6 isoform X1

See identical proteins and their annotated locations for XP_006528463.1

UniProtKB/Swiss-Prot

Q7TPS0, Q8BWZ2, Q9CUR6

UniProtKB/TrEMBL

B1B0X3, E9QK39

Conserved Domains (2) summary

cd05582
Location:193 → 507

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:542 → 828

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
XM_011247707.4 → XP_011246009.1 ribosomal protein S6 kinase alpha-6 isoform X6

UniProtKB/Swiss-Prot

Q7TPS0, Q8BWZ2, Q9CUR6

Conserved Domains (2) summary

cd05582
Location:65 → 379

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:414 → 700

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
XM_030251488.2 → XP_030107348.1 ribosomal protein S6 kinase alpha-6 isoform X5

UniProtKB/Swiss-Prot

Q7TPS0, Q8BWZ2, Q9CUR6

Conserved Domains (2) summary

cd05582
Location:114 → 428

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:463 → 744

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases