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    Dynlrb1 dynein light chain roadblock-type 1 [ Mus musculus (house mouse) ]

    Gene ID: 67068, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dynlrb1provided by MGI
    Official Full Name
    dynein light chain roadblock-type 1provided by MGI
    Primary source
    MGI:MGI:1914318
    See related
    Ensembl:ENSMUSG00000047459 AllianceGenome:MGI:1914318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DNLC2A; Dncl2a; km23-1; 2010012N15Rik; 2010320M17Rik; 9430076K19Rik
    Summary
    Enables identical protein binding activity. Predicted to be involved in microtubule-based movement and visual behavior. Part of cytoplasmic dynein complex. Is expressed in central nervous system; dorsal root ganglion; and retina. Orthologous to human DYNLRB1 (dynein light chain roadblock-type 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 150.1), whole brain E14.5 (RPKM 121.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H1; 2 77.07 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155078453..155092197)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155236533..155250277)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene itchy, E3 ubiquitin protein ligase Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene predicted gene, 52565 Neighboring gene microtubule-associated protein 1 light chain 3 alpha Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene microRNA 695

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cautionary tail: the presence of an N-terminal tag on dynein light-chain Roadblock/LC7 affects its interaction with a functional partner. Song J, et al. Protein Pept Lett, 2007. PMID 17346231
    2. N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance. Ripon MKH, et al. Cell Death Dis, 2020 Aug 14. PMID 32796833, Free PMC Article
    3. Role of km23-1 in RhoA/actin-based cell migration. Jin Q, et al. Biochem Biophys Res Commun, 2012 Nov 23. PMID 23079622, Free PMC Article
    4. The Roadblock light chains are ubiquitous components of cytoplasmic dynein that form homo- and heterodimers. Nikulina K, et al. Cell Motil Cytoskeleton, 2004 Apr. PMID 14752807
    5. DYNLRB1 is essential for dynein mediated transport and neuronal survival. Terenzio M, et al. Neurobiol Dis, 2020 Jul. PMID 32088381, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.
      Title: Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.
    2. N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance.
      Title: N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance.
    3. The presence of an N-terminal tag on dynein light-chain Roadblock/LC7 affects its interaction with a functional partner.
      Title: Cautionary tail: the presence of an N-terminal tag on dynein light-chain Roadblock/LC7 affects its interaction with a functional partner.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159313, MGC159351

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein light chain roadblock-type 1
    Names
    dynein light chain 2A, cytoplasmic
    dynein, cytoplasmic, light chain 2A
    dynein, cytoplasmic, light polypeptide 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291108.1 → NP_001278037.1  dynein light chain roadblock-type 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      CJ136086, CO041603
      Consensus CDS
      CCDS71166.1
      UniProtKB/TrEMBL
      A2AVR9
      Related
      ENSMUSP00000114928.2, ENSMUST00000150602.2
      Conserved Domains (1) summary
      smart00960
      Location:12 → 99
      Robl_LC7; Roadblock/LC7 domain

    2. NM_025947.3 → NP_080223.2  dynein light chain roadblock-type 1 isoform b

      See identical proteins and their annotated locations for NP_080223.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK166685, AL929588, CO041603
      Consensus CDS
      CCDS38294.1
      UniProtKB/Swiss-Prot
      A2AVR8, O88567, P62627, Q4FZJ8, Q9D812
      Related
      ENSMUSP00000105304.3, ENSMUST00000109682.9
      Conserved Domains (1) summary
      smart00960
      Location:4 → 91
      Robl_LC7; Roadblock/LC7 domain

    RNA

    1. NR_111890.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in its 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL929588, CJ136086, CO041603

    2. NR_111891.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK002359, AL929588, CO041603
      Related
      ENSMUST00000054912.15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155078453..155092197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62627.3 GenPept UniProtKB/Swiss-Prot:P62627

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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