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    Rbm7 RNA binding motif protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 67010, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rbm7provided by MGI
    Official Full Name
    RNA binding motif protein 7provided by MGI
    Primary source
    MGI:MGI:1914260
    See related
    Ensembl:ENSMUSG00000042396 AllianceGenome:MGI:1914260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200007M24Rik; 1500011D06Rik
    Summary
    Predicted to enable 14-3-3 protein binding activity and RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and snRNA catabolic process. Predicted to act upstream of or within meiotic cell cycle. Located in nucleus. Orthologous to human RBM7 (RNA binding motif protein 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 26.0), bladder adult (RPKM 18.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A5.3; 9 26.43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (48399997..48406630, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (48488697..48495330, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39335 Neighboring gene predicted gene, 39334 Neighboring gene STARR-seq mESC enhancer starr_24068 Neighboring gene STARR-positive B cell enhancer ABC_E3826 Neighboring gene RNA exonuclease 2 Neighboring gene STARR-positive B cell enhancer ABC_E9759 Neighboring gene predicted gene 5617 Neighboring gene STARR-seq mESC enhancer starr_24069 Neighboring gene nicotinamide N-methyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E5067 Neighboring gene STARR-seq mESC enhancer starr_24071

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis. Fukushima K, et al. Immunity, 2020 Mar 17. PMID 32187520
    2. p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex. Tiedje C, et al. RNA, 2015 Feb. PMID 25525152, Free PMC Article
    3. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. Rousseau S, et al. EMBO J, 2002 Dec 2. PMID 12456657, Free PMC Article
    4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA intronic binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326355.1 → NP_001313284.1  RNA-binding protein 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 3' splice site, compared to variant 1, which results in a frameshift and early stop codon. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA178228, AK151827, AK153504, BY087243
      UniProtKB/TrEMBL
      A0A1L1SRC3
      Conserved Domains (2) summary
      COG0724
      Location:9 → 101
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12592
      Location:9 → 83
      RRM_RBM7; RNA recognition motif in vertebrate RNA-binding protein 7 (RBM7)

    2. NM_001326356.1 → NP_001313285.1  RNA-binding protein 7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal exon , compared to variant 1, which results in a frameshift and early stop codon. It encodes isoform 3 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA178228, AI853382, AK153504, BY087243
      UniProtKB/TrEMBL
      Q3U5M9
      Conserved Domains (2) summary
      COG0724
      Location:9 → 101
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:9 → 83
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_144948.5 → NP_659197.2  RNA-binding protein 7 isoform 1

      See identical proteins and their annotated locations for NP_659197.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AA178228, AK151056, BY087243
      Consensus CDS
      CCDS23155.1
      UniProtKB/Swiss-Prot
      Q3UB91, Q7TQE3, Q9CQT2
      UniProtKB/TrEMBL
      Q14A95
      Related
      ENSMUSP00000126374.3, ENSMUST00000170000.4
      Conserved Domains (2) summary
      COG0724
      Location:9 → 101
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12592
      Location:9 → 83
      RRM_RBM7; RNA recognition motif in vertebrate RNA-binding protein 7 (RBM7)

    RNA

    1. NR_037589.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 5' coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for non-mediated mRNA decay (NMD).
      Source sequence(s)
      AA178228, AK153504, BY087243
      Related
      ENSMUST00000214923.2

    2. NR_136937.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate exon in the 5' coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for non-mediated mRNA decay (NMD).
      Source sequence(s)
      AA178228, AK005998, AK153504, BY087243

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      48399997..48406630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQT2.1 GenPept UniProtKB/Swiss-Prot:Q9CQT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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