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    Psmd5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 [ Mus musculus (house mouse) ]

    Gene ID: 66998, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Psmd5provided by MGI
    Official Full Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 5provided by MGI
    Primary source
    MGI:MGI:1914248
    See related
    Ensembl:ENSMUSG00000026869 AllianceGenome:MGI:1914248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S5b; mKIAA0072; 1500032A03Rik
    Summary
    Predicted to be involved in proteasome regulatory particle assembly. Part of proteasome accessory complex. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and integumental system. Orthologous to human PSMD5 (proteasome 26S subunit, non-ATPase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 25.4), liver E14.5 (RPKM 24.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 22.99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34742099..34760983, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34852087..34870965, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene F-box and WD-40 domain protein 2 Neighboring gene STARR-seq mESC enhancer starr_04267 Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene STARR-seq mESC enhancer starr_04268 Neighboring gene STARR-seq mESC enhancer starr_04269 Neighboring gene STARR-positive B cell enhancer ABC_E3369 Neighboring gene cutA divalent cation tolerance homolog-like Neighboring gene PHD finger protein 19 Neighboring gene STARR-positive B cell enhancer ABC_E1003

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PSMD5 Inactivation Promotes 26S Proteasome Assembly during Colorectal Tumor Progression. Levin A, et al. Cancer Res, 2018 Jul 1. PMID 29716915, Free PMC Article
    2. Role of S5b/PSMD5 in proteasome inhibition caused by TNF-α/NFκB in higher eukaryotes. Shim SM, et al. Cell Rep, 2012 Sep 27. PMID 22921402
    3. Mapping the murine cardiac 26S proteasome complexes. Gomes AV, et al. Circ Res, 2006 Aug 18. PMID 16857966
    4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0072

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome regulatory particle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of proteasome accessory complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 5
    Names
    26S protease subunit S5 basic
    26S proteasome subunit S5B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355544.1 → NP_001342473.1  26S proteasome non-ATPase regulatory subunit 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL929068
      Conserved Domains (1) summary
      pfam10508
      Location:1 → 330
      Proteasom_PSMB; Proteasome non-ATPase 26S subunit

    2. NM_080554.2 → NP_542121.2  26S proteasome non-ATPase regulatory subunit 5 isoform 1

      See identical proteins and their annotated locations for NP_542121.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK032992, AK148284, BY449619
      Consensus CDS
      CCDS15953.1
      UniProtKB/Swiss-Prot
      A2AUB0, Q3UFV2, Q5DU49, Q8BJY1, Q8BMA9, Q8VEE9
      Related
      ENSMUSP00000028225.6, ENSMUST00000028225.12
      Conserved Domains (2) summary
      pfam10508
      Location:1 → 504
      Proteasom_PSMB; Proteasome non-ATPase 26S subunit
      sd00044
      Location:88 → 112
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      34742099..34760983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319212.3 → XP_017174701.1  26S proteasome non-ATPase regulatory subunit 5 isoform X1

      Conserved Domains (1) summary
      pfam10508
      Location:1 → 275
      Proteasom_PSMB; Proteasome non-ATPase 26S subunit

    2. XM_030251975.2 → XP_030107835.1  26S proteasome non-ATPase regulatory subunit 5 isoform X1

      Conserved Domains (1) summary
      pfam10508
      Location:1 → 275
      Proteasom_PSMB; Proteasome non-ATPase 26S subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJY1.4 GenPept UniProtKB/Swiss-Prot:Q8BJY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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