Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmd12provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 12provided by MGI
Primary source: MGI:MGI:1914247
See related: Ensembl:ENSMUSG00000020720 AllianceGenome:MGI:1914247
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P55; 1500002F15Rik
Summary: Part of proteasome regulatory particle. Is expressed in several structures, including alimentary system; endocrine gland; ganglia; genitourinary system; and sensory organ. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 35.9), liver E14 (RPKM 35.0) and 24 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 E1; 11 70.29 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (107370354..107388862)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (107479528..107498036)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSMD12 promotes breast cancer growth via inhibiting the expression of pro-apoptotic genes.
Title: PSMD12 promotes breast cancer growth via inhibiting the expression of pro-apoptotic genes.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI480719 (e-PCR)
- UniSTS:180356

NoName (e-PCR)
- UniSTS:224471

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome accessory complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: 26S proteasome non-ATPase regulatory subunit 12

Names: 26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025894.2 → NP_080170.1 26S proteasome non-ATPase regulatory subunit 12

See identical proteins and their annotated locations for NP_080170.1

Status: PROVISIONAL

Source sequence(s)

AK009969

Consensus CDS

CCDS25568.1

UniProtKB/Swiss-Prot

Q9CQT4, Q9CYB3, Q9D8W5

UniProtKB/TrEMBL

Q3U8F5

Related

ENSMUSP00000021063.7, ENSMUST00000021063.13

Conserved Domains (1) summary

COG5071
Location:14 → 456

RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]