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    Cdca7 cell division cycle associated 7 [ Mus musculus (house mouse) ]

    Gene ID: 66953, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Cdca7provided by MGI
    Official Full Name
    cell division cycle associated 7provided by MGI
    Primary source
    MGI:MGI:1914203
    See related
    Ensembl:ENSMUSG00000055612 AllianceGenome:MGI:1914203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    JPO1; 2310021G01Rik
    Summary
    Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within regulation of cell population proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 3. Orthologous to human CDCA7 (cell division cycle associated 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 42.4), CNS E11.5 (RPKM 31.9) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C3; 2 43.35 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (72306540..72317237)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (72476187..72486892)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 20 Neighboring gene predicted gene, 52556 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72234732-72234933 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72235096-72235279 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72237569-72237890 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72239438-72239655 Neighboring gene STARR-seq mESC enhancer starr_04817 Neighboring gene STARR-positive B cell enhancer ABC_E9198 Neighboring gene predicted gene, 39847 Neighboring gene STARR-seq mESC enhancer starr_04819 Neighboring gene eukaryotic translation initiation factor 1, pseudogene 3 Neighboring gene predicted gene, 30069

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Heterogeneity of natural killer cell subsets in NK-1.1+ and NK-1.1- inbred mouse strains and their progeny. Morelli L, et al. Cell Immunol, 1992 Apr 15. PMID 1555248
    2. Structural basis of specific DNA binding by the transcription factor ZBTB24. Ren R, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31226215, Free PMC Article
    3. Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors. Huang YT, et al. BMC Neurosci, 2017 Jun 5. PMID 28583079, Free PMC Article
    4. The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. Osthus RC, et al. Cancer Res, 2005 Jul 1. PMID 15994934, Free PMC Article
    5. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. Hardikar S, et al. Protein Cell, 2020 Mar. PMID 31970665, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses.
      Title: CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses.
    2. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation.
      Title: The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation.
    3. The results demonstrated that the C382Y and C407G mutations in mouse ZBTB24 abolish specific DNA binding and fail to induce Cdca7 expression, modeling the events in immunodeficiency-centromeric instability-facial anomalies syndrome in humans.
      Title: Structural basis of specific DNA binding by the transcription factor ZBTB24.
    4. Pax6 normally represses Cdca7 expression in the lateral cortex and that repression of Cdca7 in cells of this region is required for their production of a normal complement of Tbr2-expressing intermediate progenitors
      Title: Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors.
    5. Transcriptome analysis identified Cdca7 as the top down-regulated gene in Zbtb24 homozygous mutant mESCs, which can be restored by ectopic ZBTB24 expression. Finally, we show that this regulation is conserved between species and that CDCA7 levels are reduced in patients carrying ZBTB24 nonsense mutations
      Title: Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle-associated protein 7
    Names
    c-Myc target JPO1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418560.1 → NP_001405489.1  cell division cycle-associated protein 7 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL845274

    2. NM_001418561.1 → NP_001405490.1  cell division cycle-associated protein 7 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL845274

    3. NM_001418562.1 → NP_001405491.1  cell division cycle-associated protein 7 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL845274

    4. NM_001418563.1 → NP_001405492.1  cell division cycle-associated protein 7 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL845274

    5. NM_025866.4 → NP_080142.1  cell division cycle-associated protein 7 isoform a

      See identical proteins and their annotated locations for NP_080142.1

      Status: VALIDATED

      Source sequence(s)
      AL845274
      Consensus CDS
      CCDS16121.1
      UniProtKB/Swiss-Prot
      Q3TIS1, Q3U511, Q6NZE5, Q8C1A0, Q9D0M2
      Related
      ENSMUSP00000099752.5, ENSMUST00000102691.11
      Conserved Domains (1) summary
      pfam10497
      Location:273 → 371
      zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

    RNA

    1. NR_184782.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845274

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      72306540..72317237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0M2.1 GenPept UniProtKB/Swiss-Prot:Q9D0M2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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