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    Acad8 acyl-Coenzyme A dehydrogenase family, member 8 [ Mus musculus (house mouse) ]

    Gene ID: 66948, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Acad8provided by MGI
    Official Full Name
    acyl-Coenzyme A dehydrogenase family, member 8provided by MGI
    Primary source
    MGI:MGI:1914198
    See related
    Ensembl:ENSMUSG00000031969 AllianceGenome:MGI:1914198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310016C19Rik
    Summary
    Predicted to enable acyl-CoA dehydrogenase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ACAD8 (acyl-CoA dehydrogenase family member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 8.3), genital fat pad adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A4; 9 12.0 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (26885434..26910872, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (26974138..26999571, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1110 Neighboring gene STARR-seq mESC enhancer starr_23615 Neighboring gene STARR-seq mESC enhancer starr_23616 Neighboring gene zinc finger CCCH type containing 11A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8282 Neighboring gene thymocyte nuclear protein 1 Neighboring gene VPS26 retromer complex component B Neighboring gene STARR-positive B cell enhancer ABC_E8283 Neighboring gene STARR-positive B cell enhancer ABC_E3819 Neighboring gene non-SMC condensin II complex, subunit D3 Neighboring gene STARR-seq mESC enhancer starr_23617

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice. Sabbagha NG, et al. Pediatr Res, 2011 Jul. PMID 21659959
    2. Mapping of genetic loci that modulate differential colonization by Escherichia coli O157:H7 TUV86-2 in advanced recombinant inbred BXD mice. Russo LM, et al. BMC Genomics, 2015 Nov 16. PMID 26573818, Free PMC Article
    3. A cellular and spatial map of the choroid plexus across brain ventricles and ages. Dani N, et al. Cell, 2021 May 27. PMID 33932339, Free PMC Article
    4. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-methylbutanoyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-methylpropanoyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within branched-chain amino acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    isobutyryl-CoA dehydrogenase, mitochondrial
    Names
    ACAD-8
    acyl-CoA dehydrogenase family member 8
    NP_080138.2
    XP_006510613.1
    XP_030100369.1
    XP_030100370.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025862.2 → NP_080138.2  isobutyryl-CoA dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080138.2

      Status: VALIDATED

      Source sequence(s)
      AC138616, AK077335, BQ931973
      Consensus CDS
      CCDS40567.1
      UniProtKB/Swiss-Prot
      Q8BK36, Q8BKQ8, Q8CFY9, Q9D2L8, Q9D7B6
      UniProtKB/TrEMBL
      A0A0R4J0P1, D3YTT4
      Related
      ENSMUSP00000054370.8, ENSMUST00000060513.8
      Conserved Domains (2) summary
      cd01162
      Location:39 → 412
      IBD; Isobutyryl-CoA dehydrogenase
      COG1960
      Location:37 → 411
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      26885434..26910872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244509.1 → XP_030100369.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q8BK36, Q8BKQ8, Q8CFY9, Q9D2L8, Q9D7B6
      UniProtKB/TrEMBL
      D3YTT4
      Conserved Domains (1) summary
      cd01162
      Location:1 → 355
      IBD; Isobutyryl-CoA dehydrogenase

    2. XM_006510550.4 → XP_006510613.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl09933
      Location:1 → 211
      ACAD; Acyl-CoA dehydrogenase

    3. XM_030244510.1 → XP_030100370.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl09933
      Location:1 → 211
      ACAD; Acyl-CoA dehydrogenase

    RNA

    1. XR_870536.4 RNA Sequence

    2. XR_001778975.3 RNA Sequence

    3. XR_003947975.2 RNA Sequence

    4. XR_001778977.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7B6.2 GenPept UniProtKB/Swiss-Prot:Q9D7B6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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