Dsn1 DSN1 homolog, MIS12 kinetochore complex component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dsn1provided by MGI
Official Full Name: DSN1 homolog, MIS12 kinetochore complex componentprovided by MGI
Primary source: MGI:MGI:1914184
See related: Ensembl:ENSMUSG00000027635 AllianceGenome:MGI:1914184
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700022L09Rik
Summary: Predicted to be involved in mitotic sister chromatid segregation. Predicted to act upstream of or within chromosome segregation. Predicted to be located in cytosol; kinetochore; and nuclear lumen. Predicted to be part of nuclear MIS12/MIND complex. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human DSN1 (DSN1 component of MIS12 kinetochore complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 10.6), CNS E11.5 (RPKM 9.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.89 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (156836982..156848995, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (156995062..157007075, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we demonstrate that interaction of monopolin subunit Csm1 with the N-terminal domain of MIND complex subunit Dsn1, is essential for both the association of monopolin with kinetochores and for monopolar attachment of sister kinetochores during meiosis
Title: Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW552447 (e-PCR)
- UniSTS:178744

NoName (e-PCR)
- UniSTS:234581

NoName (e-PCR)
- UniSTS:234582

RH127290 (e-PCR)
- UniSTS:209816

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle satellite cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MIS12/MIND type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MIS12/MIND type complex	ISO Inferred from Sequence Orthology more info
part_of MIS12/MIND type complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in spindle pole	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: kinetochore-associated protein DSN1 homolog

Names: DSN1, MIND kinetochore complex component, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.