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    Lonp2 lon peptidase 2, peroxisomal [ Mus musculus (house mouse) ]

    Gene ID: 66887, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lonp2provided by MGI
    Official Full Name
    lon peptidase 2, peroxisomalprovided by MGI
    Primary source
    MGI:MGI:1914137
    See related
    Ensembl:ENSMUSG00000047866 AllianceGenome:MGI:1914137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lonp; 1300002A08Rik
    Summary
    Predicted to enable peptidase activity and protease binding activity. Predicted to be involved in protein processing; protein targeting to peroxisome; and regulation of fatty acid beta-oxidation. Predicted to act upstream of or within proteolysis. Located in cytoplasm and nucleus. Is expressed in future brain; future prosencephalon; head; neural tube; and remnant of Rathke's pouch. Orthologous to human LONP2 (lon peptidase 2, peroxisomal). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 67.2), mammary gland adult (RPKM 34.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C3; 8 42.1 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (87350672..87443264)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (86624043..86716636)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24490 Neighboring gene STARR-seq mESC enhancer starr_22180 Neighboring gene STARR-seq mESC enhancer starr_22182 Neighboring gene ATP-binding cassette, sub-family C member 12 Neighboring gene STARR-positive B cell enhancer ABC_E10515 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:89230711-89230912 Neighboring gene predicted gene, 22305 Neighboring gene STARR-seq mESC enhancer starr_22187 Neighboring gene siah E3 ubiquitin protein ligase 1A Neighboring gene STARR-seq mESC enhancer starr_22189 Neighboring gene predicted gene 10638 Neighboring gene predicted gene, 39215

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DNMT1 interacts with the developmental transcriptional repressor HESX1. Sajedi E, et al. Biochim Biophys Acta, 2008 Jan. PMID 17931718, Free PMC Article
    2. In silico QTL mapping of basal liver iron levels in inbred mouse strains. McLachlan S, et al. Physiol Genomics, 2011 Feb 11. PMID 21062905, Free PMC Article
    3. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article
    4. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lon protease homolog 2, peroxisomal
    Names
    lon protease 2
    lon protease-like protein 2
    peroxisomal Lon protease homolog 2
    NP_001162063.1
    NP_080103.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168591.1 → NP_001162063.1  lon protease homolog 2, peroxisomal isoform 2

      See identical proteins and their annotated locations for NP_001162063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK075719, BC049090
      Consensus CDS
      CCDS52624.1
      UniProtKB/TrEMBL
      Q8BK80
      Related
      ENSMUSP00000113381.2, ENSMUST00000121673.8
      Conserved Domains (2) summary
      pfam00004
      Location:1 → 93
      AAA; ATPase family associated with various cellular activities (AAA)
      cl21678
      Location:209 → 417
      ChlI; Subunit ChlI of Mg-chelatase

    2. NM_025827.3 → NP_080103.1  lon protease homolog 2, peroxisomal isoform 1

      See identical proteins and their annotated locations for NP_080103.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132147, BC049090
      Consensus CDS
      CCDS22503.1
      UniProtKB/Swiss-Prot
      Q3TEG8, Q3TFY6, Q3TGR0, Q3UAE1, Q9DBN5
      Related
      ENSMUSP00000034141.12, ENSMUST00000034141.18
      Conserved Domains (4) summary
      COG0466
      Location:11 → 838
      Lon; ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]
      cl19481
      Location:4 → 202
      LON; Found in ATP-dependent protease La (LON)
      pfam00004
      Location:371 → 513
      AAA; ATPase family associated with various cellular activities (AAA)
      cl21678
      Location:629 → 837
      ChlI; Subunit ChlI of Mg-chelatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      87350672..87443264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBN5.1 GenPept UniProtKB/Swiss-Prot:Q9DBN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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