Adat2 adenosine deaminase, tRNA-specific 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adat2provided by MGI
Official Full Name: adenosine deaminase, tRNA-specific 2provided by MGI
Primary source: MGI:MGI:1914007
See related: Ensembl:ENSMUSG00000019808 AllianceGenome:MGI:1914007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Deadc1; 4933426M09Rik
Summary: Predicted to enable tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Predicted to act upstream of or within tRNA processing. Orthologous to human ADAT2 (adenosine deaminase tRNA specific 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 16.0), CNS E11.5 (RPKM 4.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A2; 10 4.94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (13428651..13439120)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (13552907..13563376)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.
Title: The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tRNA-specific adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables tRNA-specific adenosine-34 deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA wobble adenosine to inosine editing	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA-specific adenosine deaminase 2

Names: adenosine deaminase, tRNA-specific 2, TAD2 homolog; deaminase domain containing 1; deaminase domain-containing protein 1; tRNA-specific adenosine-34 deaminase subunit ADAT2

NP_080024.3

EC 3.5.4.33

XP_011241502.1

EC 3.5.4.33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025748.4 → NP_080024.3 tRNA-specific adenosine deaminase 2

See identical proteins and their annotated locations for NP_080024.3

Status: VALIDATED

Source sequence(s)

AC153979, AK016938, AK021291

Consensus CDS

CCDS35847.1

UniProtKB/Swiss-Prot

Q6P6J0, Q9CX14

Related

ENSMUSP00000019944.9, ENSMUST00000019944.9

Conserved Domains (1) summary

COG0590
Location:23 → 173

TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

13428651..13439120

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243200.3 → XP_011241502.1 tRNA-specific adenosine deaminase 2 isoform X1

Conserved Domains (1) summary

cd01285
Location:26 → 116

nucleoside_deaminase; Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a ...