Chmp3 charged multivesicular body protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chmp3provided by MGI
Official Full Name: charged multivesicular body protein 3provided by MGI
Primary source: MGI:MGI:1913950
See related: Ensembl:ENSMUSG00000053119 AllianceGenome:MGI:1913950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 25.1; NEDF; Vps24; CGI-49; D6Ertd286e; 4921505F14Rik; 9130011K15Rik
Summary: Predicted to enable identical protein binding activity; phospholipid binding activity; and ubiquitin-specific protease binding activity. Predicted to be involved in several processes, including endosome to lysosome transport; late endosome to vacuole transport; and regulation of endosome size. Predicted to act upstream of or within cell division. Predicted to be located in endosome; midbody; and plasma membrane. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Is expressed in brain; genitourinary system; and neural retinal epithelium. Orthologous to several human genes including RNF103-CHMP3 (RNF103-CHMP3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 24.4), cerebellum adult (RPKM 16.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.17 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (71520820..71559593)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (71543831..71582609)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126761 (e-PCR)
- UniSTS:167475

C79882 (e-PCR)
- UniSTS:207977

RH130887 (e-PCR)
- UniSTS:214171

PMC154372P1 (e-PCR)
- UniSTS:271309

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane fission	NAS Non-traceable Author Statement more info	PubMed
involved_in multivesicular body assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in multivesicular body-lysosome fusion	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endosome size	ISO Inferred from Sequence Orthology more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle fusion with vacuole	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of ESCRT III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT III complex	ISO Inferred from Sequence Orthology more info
located_in amphisome membrane	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore microtubule	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: charged multivesicular body protein 3

Names: chromatin-modifying protein 3; neuroendocrine differentiation factor; vacuolar protein sorting-associated protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355674.1 → NP_001342603.1 charged multivesicular body protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC118686

Conserved Domains (1) summary

pfam03357
Location:1 → 161

Snf7
NM_001355675.1 → NP_001342604.1 charged multivesicular body protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC118686

Conserved Domains (1) summary

pfam03357
Location:1 → 161

Snf7
NM_001361405.1 → NP_001348334.1 charged multivesicular body protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

AC118686, AK014818, BY264596

Consensus CDS

CCDS20232.1

UniProtKB/Swiss-Prot

Q9CQ10, Q9D2Z2, Q9D7A5

Related

ENSMUSP00000068410.3, ENSMUST00000065364.5

Conserved Domains (1) summary

pfam03357
Location:18 → 187

Snf7
NM_025783.4 → NP_080059.2 charged multivesicular body protein 3 isoform 1

See identical proteins and their annotated locations for NP_080059.2

Status: VALIDATED

Source sequence(s)

AI848675, AK083562, BY264596

Consensus CDS

CCDS20232.1

UniProtKB/Swiss-Prot

Q9CQ10, Q9D2Z2, Q9D7A5

Related

ENSMUSP00000109815.4, ENSMUST00000059462.12

Conserved Domains (1) summary

pfam03357
Location:18 → 187

Snf7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

71520820..71559593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506481.5 → XP_006506544.1 charged multivesicular body protein 3 isoform X1

See identical proteins and their annotated locations for XP_006506544.1

Conserved Domains (1) summary

cl21588
Location:1 → 121

Snf7
XM_030255546.2 → XP_030111406.1 charged multivesicular body protein 3 isoform X1

Conserved Domains (1) summary

cl21588
Location:1 → 121

Snf7
XM_036152263.1 → XP_036008156.1 charged multivesicular body protein 3 isoform X1

Conserved Domains (1) summary

cl21588
Location:1 → 121

Snf7