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    Acp6 acid phosphatase 6, lysophosphatidic [ Mus musculus (house mouse) ]

    Gene ID: 66659, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Acp6provided by MGI
    Official Full Name
    acid phosphatase 6, lysophosphatidicprovided by MGI
    Primary source
    MGI:MGI:1931010
    See related
    Ensembl:ENSMUSG00000028093 AllianceGenome:MGI:1931010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ACPL1; mPACPL1; 5730559A09Rik
    Summary
    Predicted to enable lysophosphatidic acid phosphatase activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human ACP6 (acid phosphatase 6, lysophosphatidic). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 20.3), large intestine adult (RPKM 18.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.1; 3 42.04 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97066070..97083892)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97158752..97176576)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24435 Neighboring gene STARR-seq mESC enhancer starr_08461 Neighboring gene STARR-seq mESC enhancer starr_08462 Neighboring gene nuclear encoded tRNA glutamic acid 12 (anticodon CTC) Neighboring gene STARR-seq mESC enhancer starr_08463 Neighboring gene B cell CLL/lymphoma 9 Neighboring gene STARR-positive B cell enhancer mm9_chr3:97031479-97031779 Neighboring gene STARR-seq mESC enhancer starr_08464 Neighboring gene predicted gene, 40101

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells. Luquain C, et al. J Lipid Res, 2003 Oct. PMID 12837850
    2. Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum. Takayama I, et al. Gut, 2002 Jun. PMID 12010880, Free PMC Article
    3. Characterization of the zinc-induced Shank3 interactome of mouse synaptosome. Lee Y, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29111324
    4. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    5. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. acid phosphatase-like protein 1 from human intestinal tissue could be associated with interstitial cells of Cajal function ACPL1
      Title: Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophosphatidic acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysobisphosphatidic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysobisphosphatidic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidic acid phosphatase type 6
    Names
    PACPL1
    acid phosphatase like 1
    acid phosphatase-like protein 1
    NP_062774.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019800.4 → NP_062774.2  lysophosphatidic acid phosphatase type 6 precursor

      See identical proteins and their annotated locations for NP_062774.2

      Status: VALIDATED

      Source sequence(s)
      AC140071, AK165356
      Consensus CDS
      CCDS17653.1
      UniProtKB/Swiss-Prot
      Q3TNE2, Q8BN33, Q8BP40, Q9JMG5, Q9QXG5
      Related
      ENSMUSP00000088263.5, ENSMUST00000090759.5
      Conserved Domains (1) summary
      cd07061
      Location:42 → 371
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      97066070..97083892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003954368.2 RNA Sequence

    2. XR_375566.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BP40.1 GenPept UniProtKB/Swiss-Prot:Q8BP40

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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