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    Ctnnbl1 catenin, beta like 1 [ Mus musculus (house mouse) ]

    Gene ID: 66642, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ctnnbl1provided by MGI
    Official Full Name
    catenin, beta like 1provided by MGI
    Primary source
    MGI:MGI:1913892
    See related
    Ensembl:ENSMUSG00000027649 AllianceGenome:MGI:1913892
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NAP; P14L; NYD-SP19; 5730471K09Rik
    Summary
    Predicted to enable enzyme binding activity. Predicted to be involved in positive regulation of apoptotic process and somatic diversification of immunoglobulins. Predicted to act upstream of or within apoptotic process. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of Prp19 complex and spliceosomal complex. Is expressed in cerebral cortex ventricular layer; embryo; limb; and limb mesenchyme. Human ortholog(s) of this gene implicated in colorectal cancer and morbid obesity. Orthologous to human CTNNBL1 (catenin beta like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 25.7), CNS E11.5 (RPKM 19.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H1; 2 78.4 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157579321..157733823)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157737401..157891903)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25407 Neighboring gene STARR-positive B cell enhancer ABC_E2055 Neighboring gene predicted gene, 23463 Neighboring gene STARR-seq mESC enhancer starr_06218 Neighboring gene STARR-seq mESC enhancer starr_06220 Neighboring gene STARR-seq mESC enhancer starr_06222 Neighboring gene ubiquitin-conjugating enzyme E2I pseudogene Neighboring gene V-set and transmembrane domain containing 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination. Han L, et al. J Immunol, 2010 Aug 1. PMID 20585033, Free PMC Article
    2. Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice. Chandra A, et al. Cell Cycle, 2013 Mar 1. PMID 23343763, Free PMC Article
    3. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Jabbour L, et al. Genomics, 2003 Mar. PMID 12659813
    4. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Korinek V, et al. Mol Cell Biol, 1998 Mar. PMID 9488439, Free PMC Article
    5. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. Ganesh K, et al. J Biol Chem, 2011 May 13. PMID 21385873, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTNNBL1 plays no essential role in cycling cells but does fulfill an evolutionarily conserved function in helping cells to undergo efficient exit from quiescence following activation.
      Title: Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice.
    2. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31
      Title: CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.
    3. Normal levels of immunoglobulin class switch recombination (CSR) factors are found in DTNNBL1-deficient cells, indicating that CTNNBL1 is dispensable for CSR.
      Title: Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21108

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somatic diversification of immunoglobulins ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-catenin-like protein 1
    Names
    nuclear protein NAP
    nuclear-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025680.4 → NP_079956.3  beta-catenin-like protein 1

      See identical proteins and their annotated locations for NP_079956.3

      Status: VALIDATED

      Source sequence(s)
      AK145598, AL663092, AL669961
      Consensus CDS
      CCDS16982.1
      UniProtKB/Swiss-Prot
      Q3UL41, Q80X64, Q8VHE3, Q9CWL8
      UniProtKB/TrEMBL
      Q3UKS4
      Related
      ENSMUSP00000029178.7, ENSMUST00000029178.7
      Conserved Domains (2) summary
      cd00020
      Location:125 → 227
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam08216
      Location:57 → 159
      CTNNBL; Catenin-beta-like, Arm-motif containing nuclear

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      157579321..157733823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500022.3 → XP_006500085.1  beta-catenin-like protein 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWL8.1 GenPept UniProtKB/Swiss-Prot:Q9CWL8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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