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    Golph3 golgi phosphoprotein 3 [ Mus musculus (house mouse) ]

    Gene ID: 66629, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Golph3provided by MGI
    Official Full Name
    golgi phosphoprotein 3provided by MGI
    Primary source
    MGI:MGI:1913879
    See related
    Ensembl:ENSMUSG00000022200 AllianceGenome:MGI:1913879
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4733401N08Rik; 5730410D03Rik
    Summary
    Predicted to enable enzyme binding activity and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; cell adhesion molecule production; and cellular response to rapamycin. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in brain; embryo; limb; liver; and notochord. Orthologous to human GOLPH3 (golgi phosphoprotein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 44.1), ovary adult (RPKM 42.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 A1; 15 5.9 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (12319617..12351687)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (12320488..12351601)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2438 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:12160369-12160618 Neighboring gene myotubularin related protein 12 Neighboring gene STARR-seq mESC enhancer starr_38019 Neighboring gene predicted gene, 46497 Neighboring gene predicted gene, 52210 Neighboring gene PDZ domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_38020 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:12365796-12365983 Neighboring gene STARR-seq mESC enhancer starr_38025 Neighboring gene predicted gene, 52211 Neighboring gene STARR-seq mESC enhancer starr_38027 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GOLPH3 Mediated Golgi Stress Response in Modulating N2A Cell Death upon Oxygen-Glucose Deprivation and Reoxygenation Injury. Li T, et al. Mol Neurobiol, 2016 Mar. PMID 25633094
    2. Identification and characterization of a novel alternative splice variant of mouse GMx33alpha/GPP34. Nagano-Ito M, et al. Gene, 2007 Oct 1. PMID 17629635
    3. miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness. Zhang Q, et al. Theranostics, 2017. PMID 29187903, Free PMC Article
    4. A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis. Xie Z, et al. Dev Cell, 2018 Mar 26. PMID 29587143, Free PMC Article
    5. The identification of novel sequences expressed in the mouse notochord. Sowden JC, et al. Mamm Genome, 1997 Jan. PMID 9021147

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Golph3 is a target gene of miR34a. miR34a/GOLPH3 axis abrogates cancer cell stemness involved in urothelial bladder cancer chemoresistance.
      Title: miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness.
    2. The current study found that GOLPH3, an outer membrane protein of the Golgi complex, was significantly upregulated in N2A cells upon oxygen-glucose deprivation and reoxygenation.
      Title: GOLPH3 Mediated Golgi Stress Response in Modulating N2A Cell Death upon Oxygen-Glucose Deprivation and Reoxygenation Injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi vesicle budding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi vesicle budding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in asymmetric Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion molecule production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to rapamycin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein retention in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Golgi phosphoprotein 3
    Names
    coat protein GPP34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025673.2 → NP_079949.1  Golgi phosphoprotein 3

      See identical proteins and their annotated locations for NP_079949.1

      Status: PROVISIONAL

      Source sequence(s)
      BC051035
      Consensus CDS
      CCDS27389.1
      UniProtKB/Swiss-Prot
      A6BLP3, Q99KY1, Q9CRA5, Q9D636
      Related
      ENSMUSP00000057375.6, ENSMUST00000059680.7
      Conserved Domains (1) summary
      pfam05719
      Location:62 → 271
      GPP34; Golgi phosphoprotein 3 (GPP34)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      12319617..12351687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520143.3 → XP_006520206.1  Golgi phosphoprotein 3 isoform X1

      Conserved Domains (1) summary
      pfam05719
      Location:60 → 227
      GPP34; Golgi phosphoprotein 3 (GPP34)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRA5.1 GenPept UniProtKB/Swiss-Prot:Q9CRA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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