Ubr7 ubiquitin protein ligase E3 component n-recognin 7 (putative) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ubr7provided by MGI
Official Full Name: ubiquitin protein ligase E3 component n-recognin 7 (putative)provided by MGI
Primary source: MGI:MGI:1913872
See related: Ensembl:ENSMUSG00000041712 AllianceGenome:MGI:1913872
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730410I19Rik
Summary: Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Is expressed in acoustic ganglion; eye; genitourinary system; and otocyst. Orthologous to human UBR7 (ubiquitin protein ligase E3 component n-recognin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 21.0), CNS E11.5 (RPKM 20.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 52.19 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (102724234..102743960)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (102757975..102777701)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data provide the first evidence of ubiquitin ligase activity in mammalian spermatozoa and indicate UBR7 involvement in spermiogenesis.
Title: Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488736

RH140485 (e-PCR)
- UniSTS:222557

AW557761 (e-PCR)
- UniSTS:185952

fj02h10.x1 (e-PCR)
- UniSTS:198303

RH124951 (e-PCR)
- UniSTS:161773

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

General protein information

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Preferred Names: putative E3 ubiquitin-protein ligase UBR7

Names: N-recognin-7; RING-type E3 ubiquitin transferase UBR7

NP_079942.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025666.2 → NP_079942.1 putative E3 ubiquitin-protein ligase UBR7

See identical proteins and their annotated locations for NP_079942.1

Status: PROVISIONAL

Source sequence(s)

AK088208

Consensus CDS

CCDS26124.1

UniProtKB/Swiss-Prot

Q80UT9, Q8BU04

UniProtKB/TrEMBL

Q3U1Z8, Q52KC0

Related

ENSMUSP00000041247.7, ENSMUST00000046404.8

Conserved Domains (2) summary

cd15542
Location:134 → 185

PHD_UBR7; PHD finger found in putative E3 ubiquitin-protein ligase UBR7

pfam02207
Location:56 → 113

zf-UBR; Putative zinc finger in N-recognin (UBR box)