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    Stoml2 stomatin (Epb7.2)-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 66592, updated on 4-May-2024

    Summary

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    Official Symbol
    Stoml2provided by MGI
    Official Full Name
    stomatin (Epb7.2)-like 2provided by MGI
    Primary source
    MGI:MGI:1913842
    See related
    Ensembl:ENSMUSG00000028455 AllianceGenome:MGI:1913842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSLP2; SLP-2; 0610038F01Rik
    Summary
    Predicted to enable GTPase binding activity and cardiolipin binding activity. Involved in several processes, including mitochondrial ATP synthesis coupled proton transport; positive regulation of interleukin-2 production; and stress-induced mitochondrial fusion. Located in mitochondrion. Is extrinsic component of plasma membrane. Orthologous to human STOML2 (stomatin like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 48.2), CNS E11.5 (RPKM 43.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A5; 4 22.99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43027690..43031402, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43027690..43031976, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1029 Neighboring gene STARR-seq mESC enhancer starr_10044 Neighboring gene Fanconi anemia, complementation group G Neighboring gene STARR-positive B cell enhancer ABC_E6165 Neighboring gene STARR-positive B cell enhancer ABC_E1642 Neighboring gene STARR-positive B cell enhancer ABC_E9237 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class O Neighboring gene STARR-positive B cell enhancer ABC_E6166 Neighboring gene atos homolog B Neighboring gene STARR-seq mESC enhancer starr_10046 Neighboring gene unc-13 homolog B Neighboring gene STARR-seq mESC enhancer starr_10047 Neighboring gene predicted gene, 23709

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function. Fan R, et al. Biochem Biophys Res Commun, 2022 Dec 25. PMID 36332472
    2. Stomatin-like protein 2 deficiency results in impaired mitochondrial translation. Mitsopoulos P, et al. PLoS One, 2017. PMID 28654702, Free PMC Article
    3. Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function. Mitsopoulos P, et al. Mol Cell Biol, 2015 May. PMID 25776552, Free PMC Article
    4. Identification of mouse mslp2 gene from EST databases by repeated searching, comparison, and assembling. Chan WL, et al. Comput Biol Med, 2006 Jan. PMID 16324911
    5. Stomatin-like protein 2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans. Feng Q, et al. Reprod Biomed Online, 2017 Feb. PMID 27986413

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. resting or activated T cells from T cell-specific Slp-2 knockout mice showed a significant impairment in the production of several mitochondrial DNA-encoded polypeptides following T cell activation. Measurement of mitochondrial DNA stability and mitochondrial transcription revealed that this impairment was at the post-transcriptional level.
      Title: Stomatin-like protein 2 deficiency results in impaired mitochondrial translation.
    2. Slp2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans
      Title: Stomatin-like protein 2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans.
    3. SLP-2 is an ABCA1-dependent regulator of raft composition and of the innate immune response.
      Title: Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling.
    4. Findings identify SLP-2 as a key regulator of the formation of respiratory chain supercomplex in vivo and show that these supercomplexes are required for optimal cell function.
      Title: Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cardiolipin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CD4-positive, alpha-beta T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress-induced mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stomatin-like protein 2, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419082.1 → NP_001406011.1  stomatin-like protein 2, mitochondrial isoform a

      Status: VALIDATED

      Source sequence(s)
      AL672276

    2. NM_001419083.1 → NP_001406012.1  stomatin-like protein 2, mitochondrial isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AL672276

    3. NM_001419084.1 → NP_001406013.1  stomatin-like protein 2, mitochondrial isoform d

      Status: VALIDATED

      Source sequence(s)
      AL672276

    4. NM_001419085.1 → NP_001406014.1  stomatin-like protein 2, mitochondrial isoform e

      Status: VALIDATED

      Source sequence(s)
      AL672276
      Related
      ENSMUSP00000117586.2, ENSMUST00000136326.8

    5. NM_001419086.1 → NP_001406015.1  stomatin-like protein 2, mitochondrial isoform f

      Status: VALIDATED

      Source sequence(s)
      AL672276

    6. NM_001419087.1 → NP_001406016.1  stomatin-like protein 2, mitochondrial isoform f

      Status: VALIDATED

      Source sequence(s)
      AL672276

    7. NM_001419088.1 → NP_001406017.1  stomatin-like protein 2, mitochondrial isoform f

      Status: VALIDATED

      Source sequence(s)
      AL672276

    8. NM_023231.3 → NP_075720.1  stomatin-like protein 2, mitochondrial isoform c

      See identical proteins and their annotated locations for NP_075720.1

      Status: VALIDATED

      Source sequence(s)
      AL672276
      Consensus CDS
      CCDS18089.1
      UniProtKB/Swiss-Prot
      Q99JB2, Q9DCG8
      UniProtKB/TrEMBL
      A2AG39
      Related
      ENSMUSP00000030169.9, ENSMUST00000030169.15
      Conserved Domains (2) summary
      COG0330
      Location:38 → 314
      HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
      cd08829
      Location:74 → 184
      SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      43027690..43031402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JB2.1 GenPept UniProtKB/Swiss-Prot:Q99JB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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