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    Cul7 cullin 7 [ Mus musculus (house mouse) ]

    Gene ID: 66515, updated on 23-Mar-2024

    Summary

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    Official Symbol
    Cul7provided by MGI
    Official Full Name
    cullin 7provided by MGI
    Primary source
    MGI:MGI:1913765
    See related
    Ensembl:ENSMUSG00000038545 AllianceGenome:MGI:1913765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p185; p193; 2510004L20Rik; C230011P08Rik
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Involved in vasculogenesis. Part of Cul7-RING ubiquitin ligase complex. Is expressed in several structures, including Meckel's cartilage; extraembryonic component; placenta; and skeleton. Human ortholog(s) of this gene implicated in 3-M syndrome. Orthologous to human CUL7 (cullin 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 31.4), placenta adult (RPKM 28.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cul7 in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46961264..46975290)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46650338..46664364)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene PTK7 protein tyrosine kinase 7 Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675 Neighboring gene STARR-positive B cell enhancer ABC_E10957 Neighboring gene kinesin light chain 4 Neighboring gene STARR-positive B cell enhancer ABC_E7536 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36 Neighboring gene STARR-positive B cell enhancer mm9_chr17:46817738-46818039 Neighboring gene kelch domain containing 3 Neighboring gene male enhanced antigen 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarction. Hassink RJ, et al. Heart, 2009 Jul. PMID 19435717, Free PMC Article
    2. Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation. Ali SH, et al. J Virol, 2004 Mar. PMID 14990695, Free PMC Article
    3. Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis. Anger M, et al. PLoS One, 2020. PMID 33351822, Free PMC Article
    4. CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes. Luo Y, et al. J Immunol, 2019 Jul 1. PMID 31092637
    5. Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling. Scheufele F, et al. Cell Signal, 2014 Feb. PMID 24219910, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Longitudinal skeletal growth and growth plate morphological characteristics of chondro-tissue specific CUL7 knockout mice.
      Title: Longitudinal skeletal growth and growth plate morphological characteristics of chondro-tissue specific CUL7 knockout mice.
    2. Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis.
      Title: Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis.
    3. this study shows that CUL7 mediates the degradation of activation-Induced Cytidine Deaminase and regulates the Ig class switch recombination in B lymphocytes
      Title: CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes.
    4. Cul7-/- mouse embryonic fibroblasts displayed an increase in the activation of AKT and Erk phosphorylation upon insulin stimulation.
      Title: Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.
    5. Expression of the dominant interfering p193 transgene results in a decrease in infarct scar expansion and preservation of myocardial function at 4 weeks after Myocardial Infarction.
      Title: Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarction.
    6. Results demonstrate a key role for the CUL7 E3 in targeting IRS-1 for degradation, a process that may contribute to the regulation of cellular senescence.
      Title: The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.
    7. suggested a role for p193/CUL7 in the regulation of apoptosis independently of p53 and Parc activity
      Title: Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding.
    8. Dimerization o Cul7 and Parc is not required for all Cul7 functions and mouse embryonic development.
      Title: Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development.
    9. role of binding of Cul7 to simian virus 40 large T antigen in cell transformation; may also regulate an important growth control pathway
      Title: Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation.
    10. Cul7 forms a heterodimeric complex with Cul1 in a manner dependent on Fbxw8.
      Title: Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in regulation of endothelial cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 3M complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul7-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul7-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cullin-7
    Names
    CUL-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025611.5 → NP_079887.3  cullin-7

      See identical proteins and their annotated locations for NP_079887.3

      Status: VALIDATED

      Source sequence(s)
      BC059865, BC065096, BY749504
      Consensus CDS
      CCDS28833.1
      UniProtKB/Swiss-Prot
      Q3UHY3, Q497I2, Q6A0D6, Q6PB63, Q8R3W4, Q8VE73, Q9CVD5
      UniProtKB/TrEMBL
      A9C491
      Related
      ENSMUSP00000049128.8, ENSMUST00000043464.14
      Conserved Domains (3) summary
      pfam11515
      Location:352 → 423
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl02148
      Location:817 → 947
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl11186
      Location:1552 → 1630
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46961264..46975290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE73.2 GenPept UniProtKB/Swiss-Prot:Q8VE73

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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