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    Mgst3 microsomal glutathione S-transferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 66447, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mgst3provided by MGI
    Official Full Name
    microsomal glutathione S-transferase 3provided by MGI
    Primary source
    MGI:MGI:1913697
    See related
    Ensembl:ENSMUSG00000026688 AllianceGenome:MGI:1913697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GST-III; 2010012L10Rik; 2010306B17Rik; 2700004G04Rik
    Summary
    Predicted to enable several functions, including glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Predicted to be involved in leukotriene biosynthetic process and lipid metabolic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Is expressed in several structures, including alimentary system; integumental system; liver; nervous system; and sensory organ. Orthologous to human MGST3 (microsomal glutathione S-transferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in stomach adult (RPKM 1980.6), duodenum adult (RPKM 1260.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H2.3; 1 74.76 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167199535..167221410, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167371966..167393841, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8779 Neighboring gene STARR-positive B cell enhancer ABC_E2583 Neighboring gene predicted gene, 24182 Neighboring gene aldehyde dehydrogenase 9, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E4378 Neighboring gene STARR-positive B cell enhancer ABC_E4379 Neighboring gene predicted gene, 34207 Neighboring gene leucine rich repeat containing 52 Neighboring gene STARR-seq mESC enhancer starr_02951 Neighboring gene STARR-seq mESC enhancer starr_02952 Neighboring gene retinoid X receptor gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Molyneaux BJ, et al. Neuron, 2015 Jan 21. PMID 25556833, Free PMC Article
    2. Quantitative trait loci for steady-state platelet count in mice. Cheung CC, et al. Mamm Genome, 2004 Oct. PMID 15520881
    3. On the integration of alcohol-related quantitative trait loci and gene expression analyses. Hitzemann R, et al. Alcohol Clin Exp Res, 2004 Oct. PMID 15597075
    4. Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis. Yao Y, et al. Nat Commun, 2020 Jul 30. PMID 32732898, Free PMC Article
    5. Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. Wu Y, et al. PLoS Genet, 2016 Sep. PMID 27689697, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-C4 synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in leukotriene biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase 3, mitochondrial
    Names
    LTC4 synthase MGST3
    glutathione peroxidase MGST3
    microsomal GST-3
    microsomal GST-III
    microsomal glutathione S-transferase III
    NP_079845.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025569.2 → NP_079845.1  glutathione S-transferase 3, mitochondrial

      See identical proteins and their annotated locations for NP_079845.1

      Status: VALIDATED

      Source sequence(s)
      AC113970, AK003246
      Consensus CDS
      CCDS15457.1
      UniProtKB/Swiss-Prot
      Q3UXC5, Q9CPU4, Q9D834
      Related
      ENSMUSP00000028005.3, ENSMUST00000028005.3
      Conserved Domains (1) summary
      pfam01124
      Location:11 → 130
      MAPEG; MAPEG family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      167199535..167221410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029392.1: Suppressed sequence

      Description
      NM_029392.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPU4.1 GenPept UniProtKB/Swiss-Prot:Q9CPU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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