Coprs coordinator of PRMT5, differentiation stimulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Coprsprovided by MGI
Official Full Name: coordinator of PRMT5, differentiation stimulatorprovided by MGI
Primary source: MGI:MGI:1913673
See related: Ensembl:ENSMUSG00000031458 AllianceGenome:MGI:1913673
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Copr5; 1700029I03Rik; 2410022L05Rik
Summary: Predicted to enable histone binding activity. Involved in muscle organ development. Acts upstream of or within blastocyst hatching. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Is expressed in early conceptus and secondary oocyte. Orthologous to human COPRS (coordinator of PRMT5 and differentiation stimulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 18.3), CNS E18 (RPKM 11.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 6.41 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (13934787..13940501, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (13884787..13890352, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It shows that in mice, genetic inactivation of coprs (which is highly expressed in testis and encodes a histone-binding protein required for the targeting of Prmt5 activity) affects the maturation of spermatogonia to spermatids.
Title: Coprs inactivation leads to a derepression of LINE1 transposons in spermatocytes.
Data extend the role of COPR5 from an adaptor protein required for nuclear functions of PRMT5 to an essential coordinator of myogenic differentiation.
Title: The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH127194 (e-PCR)
- UniSTS:208239

RH124841 (e-PCR)
- UniSTS:161663

RH134484 (e-PCR)
- UniSTS:217764

RH136099 (e-PCR)
- UniSTS:210094

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coordinator of PRMT5 and differentiation stimulator

Names: cooperator of PRMT5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359059.1 → NP_001345988.1 coordinator of PRMT5 and differentiation stimulator isoform 2

Status: VALIDATED

Source sequence(s)

AC139186

Conserved Domains (1) summary

pfam15340
Location:10 → 101

COPR5; Cooperator of PRMT5 family
NM_025556.3 → NP_079832.1 coordinator of PRMT5 and differentiation stimulator isoform 1

See identical proteins and their annotated locations for NP_079832.1

Status: VALIDATED

Source sequence(s)

AK008882, BY647791

Consensus CDS

CCDS40237.1

UniProtKB/Swiss-Prot

Q9CQ13

Related

ENSMUSP00000033839.8, ENSMUST00000033839.9

Conserved Domains (1) summary

pfam15340
Location:24 → 173

COPR5; Cooperator of PRMT5 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

13934787..13940501 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242070.4 → XP_011240372.1 coordinator of PRMT5 and differentiation stimulator isoform X1

Conserved Domains (1) summary

pfam15340
Location:24 → 46

COPR5; Cooperator of PRMT5 family