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    Nudt2 nudix hydrolase 2 [ Mus musculus (house mouse) ]

    Gene ID: 66401, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nudt2provided by MGI
    Official Full Name
    nudix hydrolase 2provided by MGI
    Primary source
    MGI:MGI:1913651
    See related
    Ensembl:ENSMUSG00000028443 AllianceGenome:MGI:1913651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APAH1; 2310051L06Rik
    Summary
    Predicted to enable bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Predicted to be involved in AMP biosynthetic process; ATP biosynthetic process; and apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human NUDT2 (nudix hydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 14.1), placenta adult (RPKM 10.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A5; 4 21.65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41465085..41480926)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41465081..41480926)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:41295845-41296146 Neighboring gene ubiquitin-associated protein 1 Neighboring gene kinesin family member 24 Neighboring gene STARR-seq mESC enhancer starr_10033 Neighboring gene STARR-positive B cell enhancer ABC_E277 Neighboring gene STARR-seq mESC enhancer starr_10034 Neighboring gene myogenesis regulating glycosidase (putative) Neighboring gene sperm microtubule inner protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NUDT2 initiates viral RNA degradation by removal of 5'-phosphates. Laudenbach BT, et al. Nat Commun, 2021 Nov 25. PMID 34824277, Free PMC Article
    2. Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells. Carmi-Levy I, et al. Mol Cell Biol, 2011 May. PMID 21402779, Free PMC Article
    3. Ap4A induces apoptosis in human cultured cells. Vartanian A, et al. FEBS Lett, 1999 Jul 30. PMID 10452553
    4. The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms. Bailey S, et al. Structure, 2002 Apr. PMID 11937063
    5. Cloning, characterisation and crystallisation of a diadenosine 5',5"'-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans. Abdelghany HM, et al. Biochim Biophys Acta, 2001 Nov 26. PMID 11738085

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.
      Title: NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.
    2. Ap4A hydrolase was found to translocate into the nuclei of mast cells following immunological activation; found its immunologically dependent association with importin beta
      Title: Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables bis(5'-nucleosyl)-tetraphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ATP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
    Names
    ap4A hydrolase
    ap4Aase
    bis(5'-nucleosyl)-tetraphosphatase
    diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
    diadenosine tetraphosphatase
    nucleoside diphosphate-linked moiety X motif 2
    nudix (nucleoside diphosphate linked moiety X)-type motif 2
    nudix motif 2
    NP_079815.2
    XP_006538228.1
    XP_011248384.1
    XP_030109557.1
    XP_036020201.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025539.2 → NP_079815.2  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

      See identical proteins and their annotated locations for NP_079815.2

      Status: VALIDATED

      Source sequence(s)
      AK018771, AK132532, CB845734
      Consensus CDS
      CCDS18061.1
      UniProtKB/Swiss-Prot
      P56380, Q9D2U6, Q9D6V2
      UniProtKB/TrEMBL
      Q3V1C8
      Related
      ENSMUSP00000030154.7, ENSMUST00000030154.7
      Conserved Domains (1) summary
      cd03428
      Location:2 → 140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41465085..41480926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164308.1 → XP_036020201.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

      UniProtKB/Swiss-Prot
      P56380, Q9D2U6, Q9D6V2
      UniProtKB/TrEMBL
      Q3V1C8
      Conserved Domains (1) summary
      cd03428
      Location:2 → 140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

    2. XM_011250082.4 → XP_011248384.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

      See identical proteins and their annotated locations for XP_011248384.1

      UniProtKB/Swiss-Prot
      P56380, Q9D2U6, Q9D6V2
      UniProtKB/TrEMBL
      Q3V1C8
      Conserved Domains (1) summary
      cd03428
      Location:2 → 140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

    3. XM_030253697.2 → XP_030109557.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

      UniProtKB/Swiss-Prot
      P56380, Q9D2U6, Q9D6V2
      UniProtKB/TrEMBL
      Q3V1C8
      Conserved Domains (1) summary
      cd03428
      Location:2 → 140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

    4. XM_006538165.4 → XP_006538228.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

      See identical proteins and their annotated locations for XP_006538228.1

      UniProtKB/Swiss-Prot
      P56380, Q9D2U6, Q9D6V2
      UniProtKB/TrEMBL
      Q3V1C8
      Conserved Domains (1) summary
      cd03428
      Location:2 → 140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56380.3 GenPept UniProtKB/Swiss-Prot:P56380

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