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    Cutc cutC copper transporter [ Mus musculus (house mouse) ]

    Gene ID: 66388, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cutcprovided by MGI
    Official Full Name
    cutC copper transporterprovided by MGI
    Primary source
    MGI:MGI:1913638
    See related
    Ensembl:ENSMUSG00000025193 AllianceGenome:MGI:1913638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-32; 2310039I18Rik
    Summary
    Predicted to enable copper ion binding activity. Predicted to be involved in copper ion homeostasis and protein tetramerization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Orthologous to human CUTC (cutC copper transporter). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.5), bladder adult (RPKM 4.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 36.67 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43741462..43757077)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43753023..43768638)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC037704 Neighboring gene STARR-positive B cell enhancer ABC_E7661 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene cytochrome c oxidase assembly protein 15 Neighboring gene STARR-positive B cell enhancer ABC_E11677 Neighboring gene STARR-positive B cell enhancer ABC_E5703 Neighboring gene ATP-binding cassette, sub-family member 2 Neighboring gene STARR-seq mESC enhancer starr_46204 Neighboring gene predicted gene 10768

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    copper homeostasis protein cutC homolog
    Names
    cutC copper transporter homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113562.1 → NP_001107034.1  copper homeostasis protein cutC homolog isoform 1

      See identical proteins and their annotated locations for NP_001107034.1

      Status: VALIDATED

      Source sequence(s)
      AK007591, BY794464
      Consensus CDS
      CCDS50443.1
      UniProtKB/Swiss-Prot
      Q9D8X1
      UniProtKB/TrEMBL
      Q9D725
      Related
      ENSMUSP00000107678.4, ENSMUST00000112047.10
      Conserved Domains (1) summary
      COG3142
      Location:26 → 268
      CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]

    2. NM_025530.3 → NP_079806.2  copper homeostasis protein cutC homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform 2 lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK009702, BP754125, BY794464
      Consensus CDS
      CCDS29837.1
      UniProtKB/TrEMBL
      F8WHX2, Q9D725
      Related
      ENSMUSP00000026199.8, ENSMUST00000026199.14
      Conserved Domains (1) summary
      COG3142
      Location:26 → 258
      CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      43741462..43757077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8X1.1 GenPept UniProtKB/Swiss-Prot:Q9D8X1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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