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    Dus2 dihydrouridine synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 66369, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dus2provided by MGI
    Official Full Name
    dihydrouridine synthase 2provided by MGI
    Primary source
    MGI:MGI:1913619
    See related
    Ensembl:ENSMUSG00000031901 AllianceGenome:MGI:1913619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dus2l; 2310016K04Rik
    Summary
    Predicted to enable several functions, including double-stranded RNA binding activity; nucleotide binding activity; and protein kinase inhibitor activity. Predicted to be involved in negative regulation of cell death and tRNA dihydrouridine synthesis. Located in mitochondrion. Is expressed in central nervous system and sensory organ. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 5.7), cerebellum adult (RPKM 5.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 D3; 8 53.07 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106738110..106780472)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106011478..106053840)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45752 Neighboring gene dipeptidase 3 Neighboring gene predicted gene, 22972 Neighboring gene dipeptidase 2 Neighboring gene DEAD box helicase 28 Neighboring gene STARR-positive B cell enhancer ABC_E1375 Neighboring gene STARR-positive B cell enhancer ABC_E3801 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108636517-108636718 Neighboring gene RIKEN cDNA 1810019D21 gene Neighboring gene epithelial splicing regulatory protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleo-mitochondrial interactions in Saccharomyces cerevisiae: characterization of a nuclear gene suppressing a defect in mitochondrial tRNA(Asp) processing. Rinaldi T, et al. Gene, 2003 Jan 16. PMID 12559567
    2. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
    3. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dihydrouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA-dihydrouridine20 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA dihydrouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA dihydrouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
    NP_001288105.1
    NP_079794.1
    XP_006531341.1
    XP_030099573.1
    XP_030099575.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301176.1 → NP_001288105.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2

      See identical proteins and their annotated locations for NP_001288105.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses a downstream translation start codon compared to isoform 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK009391, AK077451, BB596733
      UniProtKB/Swiss-Prot
      Q9D7B1
      Conserved Domains (2) summary
      cd02801
      Location:1 → 139
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cd19871
      Location:256 → 323
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

    2. NM_025518.4 → NP_079794.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

      See identical proteins and their annotated locations for NP_079794.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK009391, AK077451, BB596733
      Consensus CDS
      CCDS22627.1
      UniProtKB/Swiss-Prot
      Q6PDX2, Q9D7B1
      UniProtKB/TrEMBL
      Q14A90
      Related
      ENSMUSP00000034375.5, ENSMUST00000034375.11
      Conserved Domains (2) summary
      cd02801
      Location:13 → 252
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cd19871
      Location:369 → 436
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106738110..106780472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243713.1 → XP_030099573.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X2

      Conserved Domains (2) summary
      cd02801
      Location:75 → 223
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cd19871
      Location:340 → 407
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

    2. XM_030243715.1 → XP_030099575.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3

      Conserved Domains (2) summary
      cd02801
      Location:1 → 139
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cd19871
      Location:256 → 323
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

    3. XM_006531278.3 → XP_006531341.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1

      See identical proteins and their annotated locations for XP_006531341.1

      UniProtKB/Swiss-Prot
      Q6PDX2, Q9D7B1
      UniProtKB/TrEMBL
      Q14A90
      Conserved Domains (2) summary
      cd02801
      Location:13 → 252
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cd19871
      Location:369 → 436
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7B1.1 GenPept UniProtKB/Swiss-Prot:Q9D7B1

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