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    Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [ Mus musculus (house mouse) ]

    Gene ID: 66358, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adprmprovided by MGI
    Official Full Name
    ADP-ribose/CDP-alcohol diphosphatase, manganese dependentprovided by MGI
    Primary source
    MGI:MGI:1913608
    See related
    Ensembl:ENSMUSG00000020910 AllianceGenome:MGI:1913608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDS006; 2310004I24Rik
    Summary
    Predicted to enable 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; manganese ion binding activity; and pyrophosphatase activity. Orthologous to human ADPRM (ADP-ribose/CDP-alcohol diphosphatase, manganese dependent). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 7.4), bladder adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 40.59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (66928706..66943481, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67037880..67052631, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12299 Neighboring gene STARR-seq mESC enhancer starr_29788 Neighboring gene STARR-seq mESC enhancer starr_29789 Neighboring gene STARR-seq mESC enhancer starr_29791 Neighboring gene transmembrane protein 220 Neighboring gene STARR-seq mESC enhancer starr_29794 Neighboring gene SCO1 cytochrome c oxidase assembly protein Neighboring gene myosin, heavy polypeptide 3, skeletal muscle, embryonic Neighboring gene microRNA 6923 Neighboring gene RIKEN cDNA 2310065F04 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells. Canales J, et al. Biochem J, 2008 Jul 1. PMID 18352857
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure and function of Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase in immune tissues are reported.
      Title: Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribose diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CDP-glycerol diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
    Names
    ADP-ribose/CDP-alcohol pyrophosphatase
    ADPRibase-Mn
    CDP-choline phosphohydrolase
    NP_079786.2
    XP_006534003.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025510.3 → NP_079786.2  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

      See identical proteins and their annotated locations for NP_079786.2

      Status: VALIDATED

      Source sequence(s)
      AK145941, BY118851
      Consensus CDS
      CCDS48820.1
      UniProtKB/Swiss-Prot
      Q5SUD1, Q99KS6, Q9D7K9
      Related
      ENSMUSP00000112064.2, ENSMUST00000116363.2
      Conserved Domains (1) summary
      cd07396
      Location:18 → 322
      MPP_Nbla03831; Homo sapiens Nbla03831 and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      66928706..66943481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533940.4 → XP_006534003.1  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1

      See identical proteins and their annotated locations for XP_006534003.1

      UniProtKB/Swiss-Prot
      Q5SUD1, Q99KS6, Q9D7K9
      Conserved Domains (1) summary
      cd07396
      Location:18 → 322
      MPP_Nbla03831; Homo sapiens Nbla03831 and related proteins, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KS6.1 GenPept UniProtKB/Swiss-Prot:Q99KS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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