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    Pla2g12a phospholipase A2, group XIIA [ Mus musculus (house mouse) ]

    Gene ID: 66350, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pla2g12aprovided by MGI
    Official Full Name
    phospholipase A2, group XIIAprovided by MGI
    Primary source
    MGI:MGI:1913600
    See related
    Ensembl:ENSMUSG00000027999 AllianceGenome:MGI:1913600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GXII; Rossy; GXII-1; Pla2g12; mGXII-1; GXII-1-PLA2; 2310004B05Rik
    Summary
    Enables phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion and phospholipid metabolic process. Predicted to act upstream of or within lipid catabolic process. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PLA2G12A (phospholipase A2 group XIIA). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 52.5), ovary adult (RPKM 43.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 G3; 3 59.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129672255..129689474)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129878606..129895825)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7942 Neighboring gene GAR1 ribonucleoprotein Neighboring gene complement component factor i Neighboring gene predicted gene, 36180 Neighboring gene predicted gene, 46825 Neighboring gene caspase 6 Neighboring gene predicted gene, 40150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Induction of ectopic olfactory structures and bone morphogenetic protein inhibition by Rossy, a group XII secreted phospholipase A2. Muñoz-Sanjuán I, et al. Mol Cell Biol, 2005 May. PMID 15831466, Free PMC Article
    2. Quantitative trait locus mapping in mice identifies phospholipase Pla2g12a as novel atherosclerosis modifier. Nicolaou A, et al. Atherosclerosis, 2017 Oct. PMID 28917158
    3. A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells. Ho IC, et al. J Biol Chem, 2001 May 25. PMID 11278438
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Not Applicable (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC58884

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    group XIIA secretory phospholipase A2
    Names
    group XII-1 phospholipase A2
    group XIIA secreted phospholipase A2
    phosphatidylcholine 2-acylhydrolase 12A
    NP_001273877.1
    NP_075685.2
    NP_904359.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286948.1 → NP_001273877.1  group XIIA secretory phospholipase A2 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. The encoded protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC111097, AC118620
      Conserved Domains (1) summary
      pfam06951
      Location:27 → 154
      PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

    2. NM_023196.4 → NP_075685.2  group XIIA secretory phospholipase A2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_075685.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BB505724, BC051117
      Consensus CDS
      CCDS17836.1
      UniProtKB/Swiss-Prot
      Q3TQC4, Q9CQR3, Q9CTL1, Q9D7L3, Q9EPR1, Q9EPR2
      UniProtKB/TrEMBL
      Q6GTY5
      Related
      ENSMUSP00000029629.9, ENSMUST00000029629.15
      Conserved Domains (1) summary
      pfam06951
      Location:27 → 192
      PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

    3. NM_183423.3 → NP_904359.1  group XIIA secretory phospholipase A2 isoform 2

      See identical proteins and their annotated locations for NP_904359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC111097, AC118620
      Consensus CDS
      CCDS17837.1
      UniProtKB/Swiss-Prot
      Q9EPR2
      Related
      ENSMUSP00000053651.7, ENSMUST00000061165.9
      Conserved Domains (1) summary
      pfam06951
      Location:35 → 153
      PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

    RNA

    1. NR_104611.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC111097, AC118620

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      129672255..129689474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPR2.2 GenPept UniProtKB/Swiss-Prot:Q9EPR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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