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    Fam53c family with sequence similarity 53, member C [ Mus musculus (house mouse) ]

    Gene ID: 66306, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fam53cprovided by MGI
    Official Full Name
    family with sequence similarity 53, member Cprovided by MGI
    Primary source
    MGI:MGI:1913556
    See related
    Ensembl:ENSMUSG00000034300 AllianceGenome:MGI:1913556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm21179; 2810012G03Rik
    Summary
    Predicted to be involved in protein import into nucleus. Predicted to be active in nucleus. Orthologous to human FAM53C (family with sequence similarity 53 member C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 33.9), ovary adult (RPKM 15.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18; 18 B1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34891885..34906813)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34758831..34773760)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 25C Neighboring gene ribosomal protein L29, retrotransposed Neighboring gene STARR-positive B cell enhancer ABC_E1205 Neighboring gene RIKEN cDNA 2010110K18 gene Neighboring gene STARR-positive B cell enhancer ABC_E7575 Neighboring gene microRNA 12191 Neighboring gene predicted gene 3561 Neighboring gene STARR-positive B cell enhancer ABC_E7576 Neighboring gene STARR-seq mESC enhancer starr_44212 Neighboring gene KDM3B lysine (K)-specific demethylase 3B Neighboring gene STARR-seq mESC enhancer starr_44215 Neighboring gene receptor accessory protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM53C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357456.1 → NP_001344385.1  protein FAM53C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK044469, BC057111, CJ153142
      Consensus CDS
      CCDS29134.1
      UniProtKB/Swiss-Prot
      Q3U4J2, Q8BXQ8
      Related
      ENSMUSP00000095226.4, ENSMUST00000097622.4
      Conserved Domains (1) summary
      pfam15242
      Location:1 → 307
      FAM53; Family of FAM53

    2. NM_001357457.1 → NP_001344386.1  protein FAM53C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK044469, AK135712, BC057111, CJ153142
      UniProtKB/TrEMBL
      Q3UXE1
      Conserved Domains (1) summary
      pfam15242
      Location:8 → 270
      FAM53; Family of FAM53

    3. NM_175104.5 → NP_780313.1  protein FAM53C isoform 1

      See identical proteins and their annotated locations for NP_780313.1

      Status: VALIDATED

      Source sequence(s)
      AC145591, AK044469, BC057111, CB244539
      Consensus CDS
      CCDS29134.1
      UniProtKB/Swiss-Prot
      Q3U4J2, Q8BXQ8
      Related
      ENSMUSP00000037034.6, ENSMUST00000049281.12
      Conserved Domains (1) summary
      pfam15242
      Location:1 → 307
      FAM53; Family of FAM53

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34891885..34906813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526152.4 → XP_006526215.1  protein FAM53C isoform X1

      See identical proteins and their annotated locations for XP_006526215.1

      UniProtKB/Swiss-Prot
      Q3U4J2, Q8BXQ8
      Conserved Domains (1) summary
      pfam15242
      Location:1 → 307
      FAM53; Family of FAM53

    2. XM_006526154.5 → XP_006526217.1  protein FAM53C isoform X2

      See identical proteins and their annotated locations for XP_006526217.1

      UniProtKB/TrEMBL
      Q3UXE1
      Conserved Domains (1) summary
      pfam15242
      Location:8 → 270
      FAM53; Family of FAM53
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXQ8.1 GenPept UniProtKB/Swiss-Prot:Q8BXQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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