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    Aig1 androgen-induced 1 [ Mus musculus (house mouse) ]

    Gene ID: 66253, updated on 18-Apr-2024

    Summary

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    Official Symbol
    Aig1provided by MGI
    Official Full Name
    androgen-induced 1provided by MGI
    Primary source
    MGI:MGI:1913503
    See related
    Ensembl:ENSMUSG00000019806 AllianceGenome:MGI:1913503
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-103; 1500031O19Rik
    Summary
    Predicted to enable hydrolase activity. Predicted to be involved in long-chain fatty acid catabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in membrane. Predicted to be active in endomembrane system. Orthologous to human AIG1 (androgen induced 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 19.7), colon adult (RPKM 16.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 A2; 10 5.08 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (13522798..13744980, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13647054..13869038, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13220839-13220948 Neighboring gene STARR-seq mESC enhancer starr_25815 Neighboring gene fucosidase, alpha-L- 2, plasma Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13272745-13273072 Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene adenosine deaminase, tRNA-specific 2 Neighboring gene RIKEN cDNA A730010A20 gene Neighboring gene STARR-seq mESC enhancer starr_25816 Neighboring gene predicted gene, 53613 Neighboring gene predicted gene, 53614 Neighboring gene predicted gene, 32172 Neighboring gene predicted gene, 32105 Neighboring gene predicted gene, 22995

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Androgen-inducible gene 1 increases the ER Ca(2+) content and cell death susceptibility against oxidative stress. Nickel N, et al. Gene, 2016 Jul 15. PMID 27040980
    2. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. Erikci Ertunc M, et al. J Biol Chem, 2020 May 1. PMID 32152231, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.
      Title: AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.
    2. Immunoblotting of mouse tissues demonstrated highest expression of AIG1 in the liver, lung and heart. AIG1 has a complex genomic organization and expresses several splice variants in a tissue-dependent manner; AIG1 over-expression slightly increased susceptibility to oxidative stress. These results indicate that AIG1 plays a role in the control of the intracellular Ca(2+) concentration and cell death susceptibility.
      Title: Androgen-inducible gene 1 increases the ER Ca(2+) content and cell death susceptibility against oxidative stress.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    androgen-induced gene 1 protein
    Names
    AIG-1
    FAHFA hydrolase AIG1
    fatty acid esters of hydroxy fatty acids hydrolase AIG1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347362.1 → NP_001334291.1  androgen-induced gene 1 protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC134867, AK162306, BE985785, EF410113
      Consensus CDS
      CCDS83682.1
      UniProtKB/Swiss-Prot
      Q8CI90, Q9CW23, Q9D8B1
      UniProtKB/TrEMBL
      Q3TS32
      Related
      ENSMUSP00000125366.2, ENSMUST00000162610.8
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 219
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    2. NM_025446.4 → NP_079722.1  androgen-induced gene 1 protein isoform 1

      See identical proteins and their annotated locations for NP_079722.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC134867, AC160027, AK008210
      Consensus CDS
      CCDS23703.1
      UniProtKB/Swiss-Prot
      Q9D8B1
      Related
      ENSMUSP00000019942.6, ENSMUST00000019942.6
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 219
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      13522798..13744980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155953.1 → XP_036011846.1  androgen-induced gene 1 protein isoform X3

      UniProtKB/TrEMBL
      H7BX91
      Related
      ENSMUSP00000101174.4, ENSMUST00000105534.10
      Conserved Domains (1) summary
      pfam04750
      Location:12 → 173
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    2. XM_036155956.1 → XP_036011849.1  androgen-induced gene 1 protein isoform X5

      Conserved Domains (1) summary
      pfam04750
      Location:12 → 121
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    3. XM_030245214.2 → XP_030101074.1  androgen-induced gene 1 protein isoform X2

      Conserved Domains (1) summary
      pfam04750
      Location:12 → 167
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    4. XM_036155954.1 → XP_036011847.1  androgen-induced gene 1 protein isoform X4

      Conserved Domains (1) summary
      pfam04750
      Location:1 → 105
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    5. XM_036155955.1 → XP_036011848.1  androgen-induced gene 1 protein isoform X4

      Conserved Domains (1) summary
      pfam04750
      Location:1 → 105
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    6. XM_030245216.2 → XP_030101076.1  androgen-induced gene 1 protein isoform X4

      Conserved Domains (1) summary
      pfam04750
      Location:1 → 105
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    7. XM_006512812.4 → XP_006512875.1  androgen-induced gene 1 protein isoform X1

      Conserved Domains (1) summary
      pfam04750
      Location:12 → 167
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    8. XM_030245217.2 → XP_030101077.1  androgen-induced gene 1 protein isoform X6

      Conserved Domains (1) summary
      pfam04750
      Location:12 → 52
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    RNA

    1. XR_004936247.1 RNA Sequence

    2. XR_004936246.1 RNA Sequence

    3. XR_003948769.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8B1.2 GenPept UniProtKB/Swiss-Prot:Q9D8B1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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