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    Thoc7 THO complex 7 [ Mus musculus (house mouse) ]

    Gene ID: 66231, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Thoc7provided by MGI
    Official Full Name
    THO complex 7provided by MGI
    Primary source
    MGI:MGI:1913481
    See related
    Ensembl:ENSMUSG00000053453 AllianceGenome:MGI:1913481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nif3l1bp1
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA export from nucleus and viral mRNA export from host cell nucleus. Predicted to act upstream of or within RNA splicing and mRNA transport. Predicted to be located in cytosol and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in inferior colliculus; midbrain ventricular layer; submandibular gland primordium; telencephalon ventricular layer; and vibrissa. Orthologous to human THOC7 (THO complex 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.3), CNS E14 (RPKM 20.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 A1; 14 7.08 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (8507911..8520751)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (13949012..13961995, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 Neighboring gene ataxin 7 Neighboring gene STARR-seq mESC enhancer starr_35986 Neighboring gene predicted gene, 53821 Neighboring gene STARR-seq mESC enhancer starr_35982 Neighboring gene STARR-seq mESC enhancer starr_35981 Neighboring gene predicted gene 11100 Neighboring gene STARR-seq mESC enhancer starr_35980 Neighboring gene STARR-seq mESC enhancer starr_35979 Neighboring gene STARR-seq mESC enhancer starr_35978 Neighboring gene cadherin related family member 18 Neighboring gene zinc finger, AN1-type domain 5 pseudogene Neighboring gene predicted gene, 25964

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts. Sakuma T, et al. Viruses, 2014 Mar 10. PMID 24618812, Free PMC Article
    2. Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein. Tascou S, et al. Biochem Biophys Res Commun, 2003 Sep 19. PMID 12951069
    3. The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Wang L, et al. Cell Stem Cell, 2013 Dec 5. PMID 24315442, Free PMC Article
    4. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results imply that murine leukemia virus requires UAP56, THOC5 and THOC7, in addition to NXF1, for nuclear export of viral transcripts.
      Title: Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151296, MGC151322, 1500006O09Rik, 9230101K24Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 7 homolog
    Names
    THO complex 7 homolog
    ngg1-interacting factor 3-like protein 1-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285780.2 → NP_001272709.1  THO complex subunit 7 homolog isoform 3

      See identical proteins and their annotated locations for NP_001272709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC116479, AC171681
      UniProtKB/Swiss-Prot
      Q7TMY4
      Related
      ENSMUST00000225401.2
      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    2. NM_001359900.2 → NP_001346829.1  THO complex subunit 7 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681
      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    3. NM_001359901.2 → NP_001346830.1  THO complex subunit 7 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681
      Consensus CDS
      CCDS88568.1
      UniProtKB/TrEMBL
      A0A286YCS0, A0A286YDT0
      Related
      ENSMUSP00000153123.2, ENSMUST00000225325.2
      Conserved Domains (2) summary
      pfam05615
      Location:3 → 135
      THOC7; Tho complex subunit 7
      cl25732
      Location:78 → 195
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001426029.1 → NP_001412958.1  THO complex subunit 7 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    5. NM_001426030.1 → NP_001412959.1  THO complex subunit 7 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    6. NM_001426031.1 → NP_001412960.1  THO complex subunit 7 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    7. NM_001426032.1 → NP_001412961.1  THO complex subunit 7 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    8. NM_001426033.1 → NP_001412962.1  THO complex subunit 7 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    9. NM_001426034.1 → NP_001412963.1  THO complex subunit 7 homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    10. NM_001426035.1 → NP_001412964.1  THO complex subunit 7 homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    11. NM_001426036.1 → NP_001412965.1  THO complex subunit 7 homolog isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    12. NM_001426037.1 → NP_001412966.1  THO complex subunit 7 homolog isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    13. NM_001426038.1 → NP_001412967.1  THO complex subunit 7 homolog isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    14. NM_001426039.1 → NP_001412968.1  THO complex subunit 7 homolog isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    15. NM_001426040.1 → NP_001412969.1  THO complex subunit 7 homolog isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    16. NM_001426041.1 → NP_001412970.1  THO complex subunit 7 homolog isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    17. NM_001426042.1 → NP_001412971.1  THO complex subunit 7 homolog isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    18. NM_025435.4 → NP_079711.1  THO complex subunit 7 homolog isoform 1

      See identical proteins and their annotated locations for NP_079711.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC116479, AC171681
      Consensus CDS
      CCDS49403.1
      UniProtKB/Swiss-Prot
      Q3UIA6, Q7TMY4, Q80VT4, Q9CQ50
      UniProtKB/TrEMBL
      A0A286YDT0
      Related
      ENSMUSP00000065819.9, ENSMUST00000065865.10
      Conserved Domains (1) summary
      pfam05615
      Location:7 → 139
      THOC7; Tho complex subunit 7

    RNA

    1. NR_189660.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    2. NR_189661.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116479, AC171681

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      8507911..8520751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518078.5 → XP_006518141.1  THO complex subunit 7 homolog isoform X2

      See identical proteins and their annotated locations for XP_006518141.1

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    2. XM_030247923.2 → XP_030103783.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    3. XM_030247924.1 → XP_030103784.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    4. XM_036158791.1 → XP_036014684.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    5. XM_036158785.1 → XP_036014678.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    6. XM_030247928.1 → XP_030103788.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    7. XM_036158788.1 → XP_036014681.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    8. XM_036158789.1 → XP_036014682.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    9. XM_030247926.1 → XP_030103786.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    10. XM_036158786.1 → XP_036014679.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    11. XM_036158784.1 → XP_036014677.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    12. XM_036158790.1 → XP_036014683.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    13. XM_036158787.1 → XP_036014680.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    14. XM_030247925.1 → XP_030103785.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    15. XM_030247927.1 → XP_030103787.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    16. XM_030247931.2 → XP_030103791.1  THO complex subunit 7 homolog isoform X2

      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    RNA

    1. XR_382964.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013578.1: Suppressed sequence

      Description
      NM_001013578.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMY4.2 GenPept UniProtKB/Swiss-Prot:Q7TMY4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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