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    Acyp1 acylphosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66204, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Acyp1provided by MGI
    Official Full Name
    acylphosphatase 1provided by MGI
    Primary source
    MGI:MGI:1913454
    See related
    Ensembl:ENSMUSG00000008822 AllianceGenome:MGI:1913454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110039O14Rik
    Summary
    Predicted to enable acylphosphatase activity. Orthologous to human ACYP1 (acylphosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 42.7), cerebellum adult (RPKM 12.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 39.62 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85319172..85335257, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85272398..85288438, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene mutL homolog 3 Neighboring gene microRNA 6938 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32767 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86621244-86621431 Neighboring gene zinc finger, C2HC-type containing 1C Neighboring gene STARR-positive B cell enhancer ABC_E7161 Neighboring gene STARR-seq mESC enhancer starr_32769 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 9 Neighboring gene STARR-seq mESC enhancer starr_32770 Neighboring gene STARR-seq mESC enhancer starr_32772 Neighboring gene transmembrane p24 trafficking protein 10 Neighboring gene STARR-seq mESC enhancer starr_32773

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acylphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    acylphosphatase-1
    Names
    acylphosphatase 1, erythrocyte (common) type
    acylphosphatase, organ-common type isozyme
    acylphosphate phosphohydrolase 1
    NP_001351289.1
    NP_001351290.1
    NP_079697.1
    XP_036013450.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364360.1 → NP_001351289.1  acylphosphatase-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159237
      Consensus CDS
      CCDS88374.1
      UniProtKB/TrEMBL
      E9QJT5
      Related
      ENSMUSP00000112609.2, ENSMUST00000121930.2
      Conserved Domains (1) summary
      pfam00708
      Location:68 → 155
      Acylphosphatase

    2. NM_001364361.1 → NP_001351290.1  acylphosphatase-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159237, AK027969
      Consensus CDS
      CCDS88373.1
      UniProtKB/TrEMBL
      Q8BMV3
      Related
      ENSMUSP00000070555.8, ENSMUST00000065913.8
      Conserved Domains (1) summary
      cl00551
      Location:10 → 31
      Acylphosphatase; Acylphosphatase

    3. NM_025421.3 → NP_079697.1  acylphosphatase-1 isoform 3

      See identical proteins and their annotated locations for NP_079697.1

      Status: VALIDATED

      Source sequence(s)
      AK004176, BC096417
      Consensus CDS
      CCDS26055.1
      UniProtKB/Swiss-Prot
      P56376, Q0VG40, Q545K8, Q6P8S7
      Related
      ENSMUSP00000008966.7, ENSMUST00000008966.13
      Conserved Domains (1) summary
      pfam00708
      Location:8 → 97
      Acylphosphatase; Acylphosphatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      85319172..85335257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157557.1 → XP_036013450.1  acylphosphatase-1 isoform X1

      Conserved Domains (1) summary
      cl00551
      Location:68 → 90
      Acylphosphatase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56376.2 GenPept UniProtKB/Swiss-Prot:P56376

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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